CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002429
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methyl-accepting chemotaxis protein IV 
Protein Synonyms/Alias
 MCP-IV; Dipeptide chemoreceptor protein 
Gene Name
 tap 
Gene Synonyms/Alias
 b1885; JW1874 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
69QASTALNKAGTLTALacetylation[1]
Reference
 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 
Functional Description
 Mediates taxis toward dipeptides via an interaction with the periplasmic dipeptide-binding protein. 
Sequence Annotation
 DOMAIN 212 264 HAMP.
 DOMAIN 269 498 Methyl-accepting transducer.
 MOD_RES 293 293 Glutamate methyl ester (Gln).
 MOD_RES 300 300 Glutamate methyl ester (Gln).
 MOD_RES 307 307 Glutamate methyl ester (Gln).
 MOD_RES 489 489 Glutamate methyl ester (Glu).  
Keyword
 Cell inner membrane; Cell membrane; Chemotaxis; Complete proteome; Membrane; Methylation; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 533 AA 
Protein Sequence
MFNRIRISTT LFLILILCGI LQIGSNGMSF WAFRDDLQRL NQVEQSNQQR AALAQTRAVM 60
LQASTALNKA GTLTALSYPA DDIKTLMTTA RASLTQSTTL FKSFMAMTAG NEHVRGLQKE 120
TEKSFARWHN DLEHQATWLE SNQLSDFLTA PVQGSQNAFD VNFEAWQLEI NHVLEAASAQ 180
SQRNYQISAL VFISMIIVAA IYISSALWWT RKMIVQPLAI IGSHFDSIAA GNLARPIAVY 240
GRNEITAIFA SLKTMQQALR GTVSDVRKGS QEMHIGIAEI VAGNNDLSSR TEQQAASLAQ 300
TAASMEQLTA TVGQNADNAR QASELAKNAA TTAQAGGVQV STMTHTMQEI ATSSQKIGDI 360
ISVIDGIAFQ TNILALNAAV EAARAGEQGR GFAVVAGEVR NLASRSAQAA KEIKGLIEES 420
VNRVQQGSKL VNNAAATMID IVSSVTRVND IMGEIASASE EQQRGIEQVA QAVSQMDQVT 480
QQNASLVEEA AVATEQLANQ ADHLSSRVAV FTLEEHEVAR HESVQLQIAP VVS 533 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
 GO:0006935; P:chemotaxis; IEA:UniProtKB-KW. 
Interpro
 IPR004090; Chemotax_Me-accpt_rcpt.
 IPR003122; Chemotax_Me-accpt_rcpt_lig-bd.
 IPR004091; Chemotax_Me-accpt_rcpt_Me-site.
 IPR003660; HAMP_linker_domain.
 IPR004089; MCPsignal_dom. 
Pfam
 PF00672; HAMP
 PF00015; MCPsignal
 PF02203; TarH 
SMART
 SM00304; HAMP
 SM00283; MA
 SM00319; TarH 
PROSITE
 PS00538; CHEMOTAXIS_TRANSDUC_1
 PS50111; CHEMOTAXIS_TRANSDUC_2
 PS50885; HAMP 
PRINTS
 PR00260; CHEMTRNSDUCR.