CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025314
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17, isoform CRA_a 
Protein Synonyms/Alias
 Probable ATP-dependent RNA helicase DDX17 
Gene Name
 Ddx17 
Gene Synonyms/Alias
 mCG_13126 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
42GERLRKKKWDLSELPacetylation[1, 2]
53SELPKFEKNFYVEHPacetylation[1, 2]
195YGKCSRLKSTCIYGGacetylation[1]
205CIYGGAPKGPQIRDLubiquitination[3]
282MWSATWPKEVRQLAEacetylation[1]
282MWSATWPKEVRQLAEubiquitination[3]
436RTARSTNKGTAYTFFubiquitination[3]
449FFTPGNLKQARELIKacetylation[1]
449FFTPGNLKQARELIKubiquitination[3]
468ANQAINPKLMQLVDHacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 652 AA 
Protein Sequence
MRGGGFGDRD RDRDRGGFGA RGGSGLPPKK FGNPGERLRK KKWDLSELPK FEKNFYVEHP 60
EVARLTPYEV DELRRKKEIT VRGGDVCPKP VFAFHHANFP QYVMDVLMDQ HFTEPTPIQC 120
QGFPLALSGR DMVGIAQTGS GKTLAYLLPA IVHINHQPYL ERGDGPICLV LAPTRELAQQ 180
VQQVADDYGK CSRLKSTCIY GGAPKGPQIR DLERGVEICI ATPGRLIDFL ESGKTNLRRC 240
TYLVLDEADR MLDMGFEPQI RKIVDQIRPD RQTLMWSATW PKEVRQLAED FLRDYTQINV 300
GNLELSANHN ILQIVDVCME SEKDHKLIQL MEEIMAEKEN KTIIFVETKR RCDDLTRRMR 360
RDGWPAMCIH GDKSQPERDW VLNEFRSGKA PILIATDVAS RGLDVEDVKF VINYDYPNSS 420
EDYVHRIGRT ARSTNKGTAY TFFTPGNLKQ ARELIKVLEE ANQAINPKLM QLVDHRGGGG 480
GGGKGGRSRY RTTSSANNPN LMYQDECDRR LRGVKDGGRR DSTSYRDRSE TDRASYANGS 540
GYGSPNSAFG AQAGQYTYAQ GTYGAAAYGT SGYTAQEYAA GTYGASSTAS AGRSSQSSSQ 600
QFSGIGRSGQ QPQPLMSQQF AQPPGATNMI GYMGQTAYQY PPPPPPPPPS RK 652 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0072358; P:cardiovascular system development; IMP:MGI.
 GO:0009791; P:post-embryonic development; IMP:MGI. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000629; RNA-helicase_DEAD-box_CS.
 IPR014014; RNA_helicase_DEAD_Q_motif. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 
PRINTS