CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035261
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sodium channel protein type 4 subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 Scn4a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1715EPITTTLKRKQEEVCubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1839 AA 
Protein Sequence
MASSSLPNLV PPGPHCLRPF TPESLAAIEQ RAVEEEARLQ RNKQMEIEEP ERKPRSDLEA 60
GKNLPLIYGD PPPEVIGIPL EDLDPYYSDK KTFIVLNKGK AIFRFSATPA LYLLSPFSIV 120
RRVAIKVLIH ALPNMFIMIT ILTNCVFMTM SNPPSWSKHV EYTFTGIYTF ESLIKMLARG 180
FCIDDFTFLR DPWNWLDFSV ITMAYVTEFV DLGNISALRT FRVLRALKTI TVIPGLKTIV 240
GALIQSVKKL SDVMILTVFC LSVFALVGLQ LFMGNLRQKC VRWPPPMNDT NTTWYGNDTW 300
YSNDTWYGND TWYINDTWNS QESWAGNSTF DWEAYINDEG NFYFLEGSND ALLCGNSSDA 360
GHCPEGYECI KAGRNPNYGY TSYDTFSWAF LALFRLMTQD YWENLFQLTL RAAGKTYMIF 420
FVVIIFLGSF YLINLILAVV AMAYAEQNEA TLAEDQEKEE EFQQMLEKYK KHQEEVEKAK 480
AAQALESGEE ADGDPTHNKD CNGSLDASGE KGPPRPSCSA DSAISDAMEE LEEAHQKCPP 540
WWYKCAHKVL IWNCCAPWVK FKHIIYLIVM DPFVDLGITI CIVLNTLFMA MEHYPMTEHF 600
DNVLSVGNLV FTGIFTAEMV LKLIAMDPYE YFQQGWNIFD SFIVTLSLVE LGLANVQGLS 660
VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV LAIIVFIFAV VGMQLFGKSY 720
KECVCKIASD CNLPRWHMND FFHSFLIVFR ILCGEWIETM WDCMEVAGQA MCLTVFLMVM 780
VIGNLVVLNL FLALLLSSFS ADSLAASDED GEMNNLQIAI GRIKWGIGFA KTFLLGLLRG 840
KILSPKEIIL SLGEPGGAGE NAEESTPEDE KKEPPPEDKE LKDNHILNHV GLTDGPRSSI 900
ELDHLNFINN PYLTIHVPIA SEESDLEMPT EEETDAFSEP EDIKKPLQPL YDGNSSVCST 960
ADYKPPEEDP EEQAEENPEG EQPEECFTEA CVKRCPCLYV DISQGRGKMW WTLRRACFKI 1020
VEHNWFETFI VFMILLSSGA LAFEDIYIEQ RRVIRTILEY ADKVFTYIFI LEMLLKWVAY 1080
GFKVYFTNAW CWLDFLIVDV SIISLVANWL GYSELGPIKS LRTLRALRPL RALSRFEGMR 1140
VVVNALLGAI PSIMNVLLVC LIFWLIFSIM GVNLFAGKFY YCVNTTTSER FDISVVNNKS 1200
ECESLMYTGQ VRWMNVKVNY DNVGLGYLSL LQVATFKGWM DIMYAAVDSR EKEEQPDYEV 1260
NLYMYLYFVI FIIFGSFFTL NLFIGVIIDN FNQQKKKMRK DIFMTEEQKK YYNAMKKLGS 1320
KKPQKPIPRP QNKIQGMVYD FVTKQVFDIS IMILICLNMV TMMVETDDQS QLKVDILYNI 1380
NMVFIIIFTG ECVLKMFALR HYYFTIGWNI FDFVVVILSI VGLALSDLIQ KYFVSPTLFR 1440
VIRLARIGRV LRLIRGAKGI RTLLFALMMS LPALFNIGLL LFLVMFIYSI FGMSNFAYVK 1500
KESGIDDMFN FETFGNSIIC LFEITTSAGW DGLLNPILNS GPPDCDPTLE NPGTNVRGDC 1560
GNPSIGICFF CSYIIISFLI VVNMYIAIIL ENFNVATEES SEPLSEDDFE MFYETWEKFD 1620
PDATQFIDYS RLSDFVDTLQ EPLKIAKPNK IKLITLDLPM VPGDKIHCLD ILFALTKEVL 1680
GDSGEMDALK QTMEEKFMAA NPSKVSYEPI TTTLKRKQEE VCAIKIQRAY RRHLLQRSVK 1740
QASYMYRHSQ DGNGDGAPEK EGLLANTMNK MYGHEKEGDG VQSQGEEEKA STEDAGPTVE 1800
PKPTSSSDTA LTPSPPPLPP SSSPPQGQTV RPGVKESLV 1839 
Gene Ontology
 GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
 GO:0005248; F:voltage-gated sodium channel activity; IEA:Compara.
 GO:0035725; P:sodium ion transmembrane transport; IEA:GOC. 
Interpro
 IPR005821; Ion_trans_dom.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027359; K_channel_four-helix_dom.
 IPR008052; Na_channel_a4su.
 IPR001696; Na_channel_asu.
 IPR010526; Na_trans_assoc. 
Pfam
 PF00520; Ion_trans
 PF06512; Na_trans_assoc 
SMART
 SM00015; IQ 
PROSITE
 PS50096; IQ 
PRINTS
 PR00170; NACHANNEL.
 PR01665; NACHANNEL4.