CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019896
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hermansky-Pudlak syndrome 4 protein homolog 
Protein Synonyms/Alias
 Light-ear protein; Le protein 
Gene Name
 Hps4 
Gene Synonyms/Alias
 Le 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
662LAGKAKQKLLKHGVNacetylation[1]
Reference
 [1] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199] 
Functional Description
 May function in the pathway of organelle biogenesis. May function with HPS1. 
Sequence Annotation
  
Keyword
 Albinism; Complete proteome; Disease mutation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 671 AA 
Protein Sequence
MATTTPPETK SAAWWNYFFL YDGSKVKGEG DPTRAGICYF YPPQTLLDQQ ELLCGQLAGV 60
VRCLWDLSGT PPMLIRMRNL KFAIRADGDY LWALGCGVEI SDASCRQFLD QLIGFFHFYM 120
GPVSLAYKSH PQEELSLQWD TSITQVLRST SESHRIFNAL WNLDRTKVEP LLLLKAALIL 180
QTCQRSPHVL AGCILYKGLI VNSQLLPSLT AKVLLHQTVP ADQRLPGAGA APQETGAALP 240
PDVQITSVFL SEEEVASLHE FPVEHETRLQ GSSVQYPPWD QSSPTQAEDA WASAAIPEPT 300
PHDGACPSGS GADERLPRLE QECAGPTGLC TTACGQGSGL SSRLQKELCL SREELDSSEM 360
HVSEAQEAFP PLPALGDLET LHSSHSAPTL PEDTAICSCL HPCPLERLPE SGRLGQLADL 420
PLTNGQTQVP GTDPLPSSMP VALPPQHPVG VEPSVEPYGN GAQESHSALP RSSRSPDSPG 480
PSPSADRTGF KPSPSGRHAG LVPMNLYTHS VNGLVLSLLA EETLLSDTAA IEEVYHSSLA 540
SLNGLEVHLK ETLPRDEASL TSSTYNFLHY DRIQSVLSAN LPLVTAPQDR RFLQAVNLMH 600
SDFALLPMLY EMTIRNASTA VYACSSPAQE TYFQQLAPTA RSSGFPNPQD CAFSLAGKAK 660
QKLLKHGVNL L 671 
Gene Ontology
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0042470; C:melanosome; ISS:UniProtKB.
 GO:0016020; C:membrane; ISS:UniProtKB.
 GO:0042827; C:platelet dense granule; IEA:Compara.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0007596; P:blood coagulation; IMP:MGI.
 GO:0007040; P:lysosome organization; ISS:UniProtKB.
 GO:0030318; P:melanocyte differentiation; IMP:MGI.
 GO:0050821; P:protein stabilization; ISS:UniProtKB.
 GO:0006605; P:protein targeting; ISS:UniProtKB. 
Interpro
 IPR026091; HPS4. 
Pfam
  
SMART
  
PROSITE
  
PRINTS