CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033923
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Disks large homolog 2 
Protein Synonyms/Alias
  
Gene Name
 Dlg2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
120VSEVSHSKAVEALKEubiquitination[1]
190IDGGAAQKDGRLQVGubiquitination[1]
414DYARFEAKIHDLREQubiquitination[1]
528KPGVIDSKGDIPGLGubiquitination[1]
542GDDGYGTKTLRGQEDubiquitination[1]
694EPLMEMNKRLTEEQAubiquitination[1]
752PFIWIPSKEKL****ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 755 AA 
Protein Sequence
MLPTFDMQRP SASRAENYQL LWDTIASLKQ CEEAMQHAFI PVNGTEIEYE FEEITLERGN 60
SGLGFSIAGG TDNPHIGDDP GIFITKIIPG GAAAEDGRLR VNDCILRVNE VDVSEVSHSK 120
AVEALKEAGS IVRLYVRRRR PILETVVEIK LFKGPKGLGF SIAGGVGNQH IPGDNSIYVT 180
KIIDGGAAQK DGRLQVGDRL LMVNNYSLEE VTHEEAVAIL KNTSDVVYLK VGKPTTIYMT 240
DPYGPPDITH SYSPPMENHL LSGNNGTLEY KTSLPPISPG RYSPIPKHML GEDDYTSHSQ 300
HSTATRQPSV TLQRAISLEG EPRKVVLHKG STGLGFNIVG GEDGEGIFVS FILAGGPADL 360
SGELQRGDQI LSVNGIDLRG ASHEQAAAAL KGAGQTVTII AQYQPEDYAR FEAKIHDLRE 420
QMMNHSMSSG SGSLRTNQKR SLYVRAMFDY DKSKDSGLPS QGLSFKYGDI LHVINASDDE 480
WWQARRVTLD GDSEEMGVIP SKRRVERKER ARLKTVKFNA KPGVIDSKGD IPGLGDDGYG 540
TKTLRGQEDL ILSYEPVTRQ EINYTRPVII LGPMKDRIND DLISEFPDKF GSCVPHTTRP 600
KRDYEVDGRD YHFVISREQM EKDIQEHKFI EAGQYNDNLY GTSVQSVRFV AERGKHCILD 660
VSGNAIKRLQ VAQLYPIAIF IKPKSLEPLM EMNKRLTEEQ AKKTYDRAIK LEQEFGEYFT 720
AIVQGDTLED IYNQCKLVIE EQSGPFIWIP SKEKL 755 
Gene Ontology
 GO:0030054; C:cell junction; IDA:MGI.
 GO:0044224; C:juxtaparanode region of axon; IDA:MGI.
 GO:0045211; C:postsynaptic membrane; IDA:MGI.
 GO:0019233; P:sensory perception of pain; IMP:MGI.
 GO:0007268; P:synaptic transmission; IMP:MGI. 
Interpro
 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR016313; M-assoc_guanylate_kinase.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR019583; PDZ_assoc.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00625; Guanylate_kin
 PF00595; PDZ
 PF10600; PDZ_assoc
 PF07653; SH3_2 
SMART
 SM00072; GuKc
 SM00228; PDZ
 SM00326; SH3 
PROSITE
 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS50106; PDZ
 PS50002; SH3 
PRINTS