| Tag | Content |
|---|
| CPLM ID | CPLM-006376 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitochondrial peroxiredoxin PRX1 |
Protein Synonyms/Alias | 1-Cys PRX; Mitochondrial thiol peroxidase; mTPx; Thioredoxin reductase |
Gene Name | PRX1 |
Gene Synonyms/Alias | YBL064C; YBL0503; YBL0524 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 107 | KLKPEFDKRNVKLIG | acetylation | [1] | | 252 | FGQFNEIKPYLRFTK | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Has a thioredoxin peroxidase activity with a role in reduction of hydroperoxides. |
Sequence Annotation | DOMAIN 49 212 Thioredoxin.
ACT_SITE 91 91 By similarity.
MOD_RES 53 53 Phosphoserine. |
Keyword | Antioxidant; Complete proteome; Mitochondrion; Oxidoreductase; Peroxidase; Phosphoprotein; Redox-active center; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 261 AA |
Protein Sequence | MFSRICSAQL KRTAWTLPKQ AHLQSQTIKT FATAPILCKQ FKQSDQPRLR INSDAPNFDA 60
DTTVGKINFY DYLGDSWGVL FSHPADFTPV CTTEVSAFAK LKPEFDKRNV KLIGLSVEDV 120
ESHEKWIQDI KEIAKVKNVG FPIIGDTFRN VAFLYDMVDA EGFKNINDGS LKTVRSVFVI 180
DPKKKIRLIF TYPSTVGRNT SEVLRVIDAL QLTDKEGVVT PINWQPADDV IIPPSVSNDE 240
AKAKFGQFNE IKPYLRFTKS K 261 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:SGD. GO:0008379; F:thioredoxin peroxidase activity; IDA:SGD. GO:0045454; P:cell redox homeostasis; IMP:SGD. GO:0034599; P:cellular response to oxidative stress; IGI:SGD. GO:0046686; P:response to cadmium ion; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |