CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032274
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein transport protein Sec31A 
Protein Synonyms/Alias
 SEC31A protein 
Gene Name
 SEC31A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
78KLIWGPYKMDSKGDVubiquitination[1]
111SKIIAGDKEVVIAQNubiquitination[2]
120VVIAQNDKHTGPVRAacetylation[3]
488FEDDSRGKYLELLGYubiquitination[2]
608IVESCDLKNWREALAubiquitination[4]
690EKVVILRKAVQLTQAubiquitination[1]
1056PTKKITKKPIPDEHLubiquitination[5]
1066PDEHLILKTTFEDLIubiquitination[5]
1086SATDPQTKRKLDDASubiquitination[1]
1163VVLTQANKLGV****ubiquitination[1, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1166 AA 
Protein Sequence
MKLKEVDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL SDPSLDMKSC 60
ATFSSSHRYH KLIWGPYKMD SKGDVSGVLI AGGENGNIIL YDPSKIIAGD KEVVIAQNDK 120
HTGPVRALDV NIFQTNLVAS GANESEIYIW DLNNFATPMT PGAKTQPPED ISCIAWNRQV 180
QHILASASPS GRATVWDLRK NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV 240
IQMWDLRFAS SPLRVLENHA RGILAIAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP 300
TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSTDG LRQKQVDKLS SSFGNLDPFG 360
TGQPLPPLQI PQQTAQHSIV LPLKKPPKWI RRPVGASFSF GGKLVTFENV RMPSHQGAEQ 420
QQQQHHVFIS QVVTEKEFLS RSDQLQQAVQ SQGFINYCQK KIDASQTEFE KNVWSFLKVN 480
FEDDSRGKYL ELLGYRKEDL GKKHIKEEKE ESEFLPSSGG TFNISVSGDI DGLITQALLT 540
GNFESAVDLC LHDNRMADAI ILAIAGGQEL LARTQKKYFA KSQSKITRLI TAVVMKNWKE 600
IVESCDLKNW REALAAVLTY AKPDEFSALC DLLGTRLENE GDSLLQTQAC LCYICAGNVE 660
KLVACWTKAQ DGSHPLSLQD LIEKVVILRK AVQLTQAMDT STVGVLLAAK MSQYANLLAA 720
QGSIAAALAF LPDNTNQPNI MQLRDRLCRA QGEPVAGHES PKIPYEKQQL PKGRPGPVAG 780
HHQMPRVQTQ QYYPHGENPP PPGFIMHGNV NPNAAGQLPT SPGHMHTQVP PYPQPQPYQP 840
AQPYPFGTGG SAMYRPQQPV APPTSNAYPN TPYISSASSY TGQSQLYAAQ HQASSPTSSP 900
ATSFPPPPSS GASFQHGGPG APPSSSAYAL PPGTTGPQNG WNDPPALNRV PKKKKMPENF 960
MPPVPITSPI MNPLGDPQSQ MLQQQPSAPV PLSSQSSFPQ PHLPGGQPFH GVQQPLGQTG 1020
MPPSFSKPNI EGAPGAPIGN TFQHVQSLPT KKITKKPIPD EHLILKTTFE DLIQRCLSSA 1080
TDPQTKRKLD DASKRLEFLY DKLREQTLSP TITSGLHNIA RSIETRNYSE GLTMHTHIVS 1140
TSNFSETSAF MPVLKVVLTQ ANKLGV 1166 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS