UniProt Accession

 H2AZ_RAT; P0C0S7; P17317; Q5U5H6 

Genbank Protein ID

 X52316; M37584; BC060564; BC086348 

Genbank Nucleotide ID

 CAA36552.1; AAA41329.1; AAH60564.1; AAH86348.1 

Protein Name

 Histone H2A.Z 

Protein Synonyms/Alias

 H2A/z 

Gene Name

 H2afz 

Gene Synonyms/Alias

 H2az 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
12	KAGKDSGKAKTKAVS	acetylation	[1]
14	GKDSGKAKTKAVSRS	acetylation	[1]
126	IGKKGQQKTV*****	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). 

Sequence Annotation

 REGION 2 17 Required for interaction with INCENP (By
 REGION 93 103 Required for interaction with INCENP (By
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 5 5 N6-acetyllysine (By similarity).
 MOD_RES 8 8 N6-acetyllysine (By similarity).
 MOD_RES 12 12 N6-acetyllysine (By similarity).
 MOD_RES 14 14 N6-acetyllysine (By similarity).
 CROSSLNK 122 122 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 128 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR002119; Histone_H2A. 

Pfam

 PF00125; Histone 

SMART

 SM00414; H2A 

PROSITE

 PS00046; HISTONE_H2A 

PRINTS

 PR00620; HISTONEH2A.