UniProt Accession

 E2QRF9_HUMAN; E2QRF9 

Genbank Protein ID

 AL133264 

Genbank Nucleotide ID

  

Protein Name

 Geminin 

Protein Synonyms/Alias

  

Gene Name

 GMNN 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
91	ESFDLMIKENPSSQY	ubiquitination	[1]
127	LHKEIEQKDNEIARL	ubiquitination	[2]
139	ARLKKENKELAEVAE	ubiquitination	[3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 179 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0045786; P:negative regulation of cell cycle; IEA:Compara.
 GO:0008156; P:negative regulation of DNA replication; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0009887; P:organ morphogenesis; IEA:Compara.
 GO:0006461; P:protein complex assembly; IEA:Compara. 

Interpro

 IPR022786; Geminin_fam. 

Pfam

 PF07412; Geminin 

SMART

  

PROSITE

  

PRINTS