UniProt Accession

 SYJ2B_MOUSE; Q9D6K5; Q2TTN6; Q6YNE6; Q78HT9; Q8K4F3; Q9D8G4 

Genbank Protein ID

 AF414433; AY071903; AY157057; AY138960; AY566156; AK008054; AK013474; AK033514; AK163362; BC027433 

Genbank Nucleotide ID

 AAM43958.1; AAL60065.1; AAO12271.1; AAN17786.1; AAT70239.1; BAB25432.1; BAB28873.1; BAC28333.1; BAE37317.1; AAH27433.2 

Protein Name

 Synaptojanin-2-binding protein 

Protein Synonyms/Alias

 Activin receptor-interacting protein 2; Activin receptor-interacting protein 4; Mitochondrial outer membrane protein 25 

Gene Name

 Synj2bp 

Gene Synonyms/Alias

 Arip2; Omp25 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
64	GRLQEGDKILSVNGQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Isoform 1 regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. Isoform 2 and isoform 3 show a stimulatory affect on activin- induced signal transduction and enhance activin type 2 expression at the cell surface. 

Sequence Annotation

 DOMAIN 13 100 PDZ.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Endocytosis; Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 145 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0031307; C:integral to mitochondrial outer membrane; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0048312; P:intracellular distribution of mitochondria; IEA:Compara.
 GO:0032926; P:negative regulation of activin receptor signaling pathway; IDA:UniProtKB.
 GO:0032927; P:positive regulation of activin receptor signaling pathway; IDA:UniProtKB.
 GO:2000010; P:positive regulation of protein localization to cell surface; IDA:UniProtKB.
 GO:0002092; P:positive regulation of receptor internalization; IDA:UniProtKB. 

Interpro

 IPR001478; PDZ. 

Pfam

 PF00595; PDZ 

SMART

 SM00228; PDZ 

PROSITE

 PS50106; PDZ 

PRINTS