UniProt Accession

 AT1B1_MOUSE; P14094 

Genbank Protein ID

 X16646; BC027319; X61433 

Genbank Nucleotide ID

 CAA34639.1; AAH27319.1; CAA43675.1 

Protein Name

 Sodium/potassium-transporting ATPase subunit beta-1 

Protein Synonyms/Alias

 Sodium/potassium-dependent ATPase subunit beta-1 

Gene Name

 Atp1b1 

Gene Synonyms/Alias

 Atp4b 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
14	KEEGSWKKFIWNSEK	ubiquitination	[1]
21	KFIWNSEKKEFLGRT	ubiquitination	[1]
217	LPVQCTGKRDEDKDK	ubiquitination	[1]
289	ENIGYSEKDRFQGRF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. 

Sequence Annotation

 REGION 191 304 immunoglobulin-like (By similarity).
 MOD_RES 101 101 Phosphotyrosine.
 CARBOHYD 158 158 N-linked (GlcNAc...).
 CARBOHYD 163 163 N-linked (GlcNAc...); atypical.
 CARBOHYD 193 193 N-linked (GlcNAc...) (By similarity).
 CARBOHYD 266 266 N-linked (GlcNAc...).
 DISULFID 126 149 By similarity.
 DISULFID 159 175 By similarity.
 DISULFID 214 277 By similarity.  

Keyword

 Cell adhesion; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Potassium; Potassium transport; Reference proteome; Signal-anchor; Sodium; Sodium transport; Sodium/potassium transport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 304 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0005901; C:caveola; IEA:Compara.
 GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:Compara.
 GO:0005391; F:sodium:potassium-exchanging ATPase activity; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0001666; P:response to hypoxia; IEA:Compara. 

Interpro

 IPR000402; Na/K_ATPase_sub_beta.
 IPR015565; Na/K_ATPase_sub_beta_chordates. 

Pfam

 PF00287; Na_K-ATPase 

SMART

  

PROSITE

 PS00390; ATPASE_NA_K_BETA_1
 PS00391; ATPASE_NA_K_BETA_2 

PRINTS