| Tag | Content |
|---|
| CPLM ID | CPLM-014797 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | FYVE, RhoGEF and PH domain-containing protein 6 |
Protein Synonyms/Alias | |
Gene Name | Fgd6 |
Gene Synonyms/Alias | Kiaa1362 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1109 | MLSLAGMKVRKPTQE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). |
Sequence Annotation | DOMAIN 841 1030 DH.
DOMAIN 1059 1153 PH 1.
DOMAIN 1302 1398 PH 2.
ZN_FING 1191 1250 FYVE-type.
MOD_RES 494 494 Phosphoserine.
MOD_RES 670 670 Phosphoserine (By similarity).
MOD_RES 697 697 Phosphoserine (By similarity).
MOD_RES 1167 1167 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Guanine-nucleotide releasing factor; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1399 AA |
Protein Sequence | MTSAAELKKP PLAPKPKLVG TNNKPPPPPI APKPDIGSAS VPRLTKKTKP AIAPKPKVPT 60
NSVVQDIKHP PSKKPTLNLE EREPELPEST GKSNCKDVRD PHSDYILPTC SCSSGCIHEP 120
RTRETQCVEQ LVLEPLGMKE NLENSKNGES SKRGSSWDSS SEKCRGQSGV VLKASILEEK 180
LKEVLTQQRS PCGSPGRHRA PKKPEMNGDH SCTRQIRIEF ADVSSSLTGF EKVPAHHNCH 240
PQLPRDESQT LKTCQDGSAE SRGHTDSCEP ENKRVASDGI SQKTEVKGLG PLEIHLLPYT 300
SKFPTPKPRK THAAARLRRQ KHVDTPGEST EEPGNSNNGS SCLLEDYCLK NNKVSVLRQN 360
ALYNQGPVDE VRPANQRALT GDSNSGGQDS VGSQKAVQQQ TPSLDTDSSL TSDSSGSGVS 420
PAVDKETTYT QCSTQPLSLP KQVTSACTDQ PPATCNPEVS APPIQKESSS SRIIPKKPQR 480
HSLPAAGVLK KAASEELVEK SSSGKETNVE KGLHRNYLHH PGPPNHGASA SPFDMPNPTS 540
EKPVWKLPHP ILPFSGSPEA LKRVTLSLNN EPSVSLTKPR AKSLSAVDAD RCNKPCKDPP 600
KKTSFKKLIN VKLSIGFIKS DFQKIRSKSC QHGDVSAGHP LAREPKGLES DWQGLATGEE 660
KRSKPTKAHS AENCSLESQK VKSWGQSSAV NGQRAESLDD RILSRHTSCT GDFGPEYENV 720
RHYEEIPEYE NLPFVMAGRN TPDLGWQNSS SVEDTDASLY EVEEPYNAPD GQLQLDPRHQ 780
PCSSGTSQEG KDALHLGLSD LPSDEEVINS SDEDDVSSES SKGEPDPLED KQDEDAGMKS 840
KVHHIAKEIM SSEKVFVDVL KLLHIDFRGA VAHASRQLGK PVIEDRILNQ ILYYLPQLYE 900
LNRDLLKELE ERMLTWTEQQ RIADIFVKKG PYLKMYSTYI KEFDKNVALL DEQCKKNPGF 960
AAVVREFEMS PRCANLALKH YLLKPVQRIP QYRLLLTDYL KNLLEDSVDH RDTQDALAVV 1020
IEVANHANDT MKQGDNFQKL MQIQYSLSGH HEIVQPGRVF LKEGTLMKLS RKVMQPRMFF 1080
LFNDALLYTT PMQSGMYKLN NMLSLAGMKV RKPTQEAYQN ELKIESVERS FILSASSAAE 1140
RDDWLEAISS SIEEYAKKRI TFCPSRSLDE DSERKEEVSP LGAKAPIWIP DTRATMCMIC 1200
TSEFTLTWRR HHCRACGKIV CQACSSNKYG LDYLKGQLAR VCEHCFQELQ KLDHQLSPRV 1260
GSPGNHKSPS SALSSVLHSI PSGRKQKKIP AALKEVSANT EDSTMSGYLY RSKGSKKPWK 1320
HLWFVIKNKV LYTYAASEDV AALESQPLLG FTVTLVKDEN SESKVFQLLH KGMVFYVFKA 1380
DDAHSTQRWI DAFQEGTVL 1399 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |