UniProt Accession

 MRGBP_HUMAN; Q9NV56 

Genbank Protein ID

 AK001776; AL035669; BC009889; BC014235; BC018841 

Genbank Nucleotide ID

 BAA91902.1; CAC12748.1; AAH09889.1; AAH14235.1; AAH18841.1 

Protein Name

 MRG/MORF4L-binding protein 

Protein Synonyms/Alias

 MRG-binding protein 

Gene Name

 MRGBP 

Gene Synonyms/Alias

 C20orf20 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
152	SSSGSLGKASEKSSK	acetylation	[1]
185	KRSRVTDKVLTANSN	acetylation	[1, 2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. 

Sequence Annotation

 MOD_RES 2 2 N-acetylglycine.
 MOD_RES 191 191 Phosphoserine.
 MOD_RES 195 195 Phosphoserine.  

Keyword

 Acetylation; Activator; Chromatin regulator; Complete proteome; Direct protein sequencing; Growth regulation; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0043189; C:H4/H2A histone acetyltransferase complex; IEA:InterPro.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR012423; EAF7. 

Pfam

 PF07904; Eaf7 

SMART

  

PROSITE

  

PRINTS