CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039037
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Myh2 
Protein Synonyms/Alias
  
Gene Name
 Myh1 
Gene Synonyms/Alias
 Myh2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
44SVFVVDAKESFVKATacetylation[1]
73GGATVTVKDDQVFPMacetylation[1]
387DGTEVADKAAYLQNLacetylation[1]
401LNSADLLKALCYPRVacetylation[1]
811LARVEYQKMVERRESacetylation[1]
855LKSAETEKEMANMKEacetylation[1]
861EKEMANMKEEFEKTKacetylation[1]
866NMKEEFEKTKENLAKacetylation[1]
873KTKENLAKAEAKRKEacetylation[1]
928IQLEAKIKEVTERAEacetylation[1]
999GLDETIAKLTKEKKAacetylation[1]
1034TLTKAKIKLEQQVDDacetylation[1]
1050EGSLEQEKKIRMDLEacetylation[1]
1081TMDVENDKQQLDEKLacetylation[1]
1087DKQQLDEKLKKKEFEacetylation[1]
1248SNMEVISKSKGNLEKacetylation[1]
1255KSKGNLEKMCRTLEDacetylation[1]
1268EDQVSELKTKEEEQQacetylation[1]
1270QVSELKTKEEEQQRLacetylation[1]
1302YSRQLDEKDSLVSQLacetylation[1]
1418HVEAVNAKCASLEKTacetylation[1]
1452AACAALDKKQRNFDKacetylation[1]
1459KKQRNFDKILAEWKQacetylation[1]
1465DKILAEWKQKYEETHacetylation[1]
1467ILAEWKQKYEETHAEacetylation[1]
1480AELEASQKESRSLSTacetylation[1]
1491SLSTELFKIKNAYEEacetylation[1]
1493STELFKIKNAYEESLacetylation[1]
1529EQIAEGGKRIHELEKacetylation[1]
1539HELEKIKKQIEQEKSacetylation[1]
1545KKQIEQEKSELQAALacetylation[1]
1565SLEHEEGKILRIQLEacetylation[1]
1624NDAIRIKKKMEGDLNacetylation[1]
1625DAIRIKKKMEGDLNEacetylation[1]
1659RNTQGILKDTQLHLDacetylation[1]
1676LRGQEDLKEQLAMVEacetylation[1]
1799KNLEQTVKDLQHRLDacetylation[1]
1839GEVENEQKRNVEAIKacetylation[1]
1846KRNVEAIKGLRKHERacetylation[1]
1878RLQDLVDKLQSKVKAacetylation[1]
1882LVDKLQSKVKAYKRQacetylation[1]
1938KSREVHTKIISEE**acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; ATP-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1943 AA 
Protein Sequence
MSSDAEMAVF GEAAPYLRKS EKERIEAQNK PFDAKSSVFV VDAKESFVKA TVQSREGGKV 60
TAKTEGGATV TVKDDQVFPM NPPKYDKIED MAMMTHLHEP AVLYNLKERY AAWMIYTYSG 120
LFCVTVNPYK WLPVYNAEVV AAYRGKKRQE APPHIFSISD NAYQFMLTDR ENQSILITGE 180
SGAGKTVNTK RVIQYFATIA VTGEKKKEEA PSGKMQGTLE DQIISANPLL EAFGNAKTVR 240
NDNSSRFGKF IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL 300
IEMLLITTNP YDYAFVSQGE ITVPSIDDXQ EELMATDSAI DILGFTSDER VSIYKLTGAV 360
MHYGNMKFKQ KQREEQAEPD GTEVADKAAY LQNLNSADLL KALCYPRVKV GNEYVTKGQT 420
VQQVYNAVGA LAKAVYEKMF LWMVTRINQQ LDTKQPRQYF IGVLDIAGFE IFDFNSLEQL 480
CINFTNEKLQ QFFNHHMFVL EQEEYKKEGI EWEFIDFGMD LAACIELIEK PMGIFSILEE 540
ECMFPKATDT SFKNKLYEQH LGKSNNFQKP KPAKGKVEAH FSLVHYAGTV DYNIAGWLDK 600
NKDPLNETVV GLYQKSSMKT LAYLFSGAAA AAEAESGGGG GKKGAKKKGS SFQTVSALFR 660
ENLNKLMTNL RSTHPHFVRC IIPNETKTPG AMEHELVLHQ LRCNGVLEGI RICRKGFPSR 720
ILYADFKQRY KVLNASAIPE GQFIDSKKAS EKLLGSIDID HTQYKFGHTK VFFKAGLLGL 780
LEEMRDDKLA QLITRTQAMC RGYLARVEYQ KMVERRESIF CIQYNVRAFM NVKHWPWMKL 840
YFKIKPLLKS AETEKEMANM KEEFEKTKEN LAKAEAKRKE LEEKMVALMQ EKNDLQLQVQ 900
SEADSLADAE ERCDQLIKTK IQLEAKIKEV TERAEDEEEI NAELTAKKRK LEDECSELKK 960
DIDDLELTLA KVEKEKHATE NKVKNLTEEM AGLDETIAKL TKEKKALQEA HQQTLDDLQA 1020
EEDKVNTLTK AKIKLEQQVD DLEGSLEQEK KIRMDLERAK RKLEGDLKLA QESTMDVEND 1080
KQQLDEKLKK KEFEMSNLQS KIEDEQALGM QLQKKIKELQ ARIEELEEEI EAERASRAKA 1140
EKQRSDLSRE LEEISERLEE AGGATSAQIE MNKKREAEFQ KMRRDLEEAT LQHEATAATL 1200
RKKHADSVAE LGEQIDNLQR VKQKLEKEKS EMKMEIDDLA SNMEVISKSK GNLEKMCRTL 1260
EDQVSELKTK EEEQQRLINE LTAQRGRLQT ESGEYSRQLD EKDSLVSQLS RGKQAFTQQI 1320
EELKRQLEEE VKAKSALAHA LQSSRHDCDL LREQYEEEQE AKAELQRAMS KANSEVAQWR 1380
TKYETDAIQR TEELEEAKKK LAQRLQDAEE HVEAVNAKCA SLEKTKQRLQ NEVEDLMIDV 1440
ERTNAACAAL DKKQRNFDKI LAEWKQKYEE THAELEASQK ESRSLSTELF KIKNAYEESL 1500
DQLETLKREN KNLQQEISDL TEQIAEGGKR IHELEKIKKQ IEQEKSELQA ALEEAEASLE 1560
HEEGKILRIQ LELNQVKSEI DRKIAEKDEE IDQLKRNHIR VVESMQSTLD AEIRSRNDAI 1620
RIKKKMEGDL NEMEIQLNHS NRMAAEALRN YRNTQGILKD TQLHLDDALR GQEDLKEQLA 1680
MVERRANLLQ AEIEELRATL EQTERSRKIA EQELLDASER VQLLHTQNTS LINTKKKLET 1740
DISQIQGEME DIVQEARNAE EKAKKAITDA AMMAEELKKE QDTSAHLERM KKNLEQTVKD 1800
LQHRLDEAEQ LALKGGKKQI QKLEARVREL EGEVENEQKR NVEAIKGLRK HERRVKELTY 1860
QTEEDRKNVL RLQDLVDKLQ SKVKAYKRQA EEAEEQSNVN LAKFRKIQHE LEEAEERADI 1920
AESQVNKLRV KSREVHTKII SEE 1943 
Gene Ontology
 GO:0031672; C:A band; IEA:Compara.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0005859; C:muscle myosin complex; IDA:RGD.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; TAS:RGD.
 GO:0000146; F:microfilament motor activity; TAS:RGD.
 GO:0006941; P:striated muscle contraction; TAS:RGD. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR015650; Myosin_1/23/4/7/8/13/15.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.