CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028952
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 
Protein Synonyms/Alias
  
Gene Name
 DDAH2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51EHGVLGGKLRQRLGLacetylation[1]
105PEVDGVRKALQDLGLubiquitination[2]
194GSSDAAQKAVRAMAVubiquitination[2, 3]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 225 AA 
Protein Sequence
MGTPGEGLGR CSHALIRGVP ESLASGEGAG AGLPALDLAK AQREHGVLGG KLRQRLGLQL 60
LELPPEESLP LGPLLGDTAV IQGDTALITR PWSPARRPEV DGVRKALQDL GLRIVEIGDE 120
NATLDGTDVL FTGREFFVGL SKWTNHRGAE IVADTFRDFA VSTVPVSGPS HLRGLCGMGG 180
PRTVVAGSSD AAQKAVRAMA VLTDHPYASL TLPDDAAADC LFLRP 225 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0016597; F:amino acid binding; IEA:Compara.
 GO:0016813; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; IEA:InterPro.
 GO:0006525; P:arginine metabolic process; IEA:Compara. 
Interpro
 IPR003198; Amidino_trans. 
Pfam
 PF02274; Amidinotransf 
SMART
  
PROSITE
  
PRINTS