CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006325
UniProt Accession
Genbank Protein ID
 L05628; AF022853; AF022827; AF022828; AF022829; AF022831; AF022833; AF022835; AF022837; AF022839; AF022841; AF022850; AF022849; AF022848; AF022847; AF022846; AF022845; AF022844; AF022843; AF022842; AF022852; AF022851; AF022840; AF022838; AF022836; AF022834; AF022832; AF022826; AF022825; AF022824; AF022830; AF022853; AF022824; AF022825; AF022826; AF022828; AF022830; AF022832; AF022834; AF022836; AF022838; AF022848; AF022847; AF022846; AF022845; AF022844; AF022843; AF022842; AF022841; AF022839; AF022852; AF022851; AF022850; AF022849; AF022837; AF022835; AF022833; AF022831; AF022829; AF022827; AF022853; AF022824; AF022825; AF022826; AF022827; AF022829; AF022831; AF022833; AF022835; AF022837; AF022847; AF022846; AF022845; AF022844; AF022843; AF022842; AF022841; AF022840; AF022838; AF022852; AF022851; AF022850; AF022849; AF022848; AF022836; AF022834; AF022832; AF022830; AF022828; AF022853; AF022824; AF022825; AF022826; AF022827; AF022828; AF022829; AF022830; AF022831; AF022832; AF022833; AF022834; AF022835; AF022836; AF022837; AF022838; AF022839; AF022840; AF022841; AF022842; AF022843; AF022844; AF022845; AF022846; AF022847; AF022848; AF022849; AF022850; AF022851; EF419769; AC025778; AC130651; AC136624; AB209120; U91318; AC003026 
Genbank Nucleotide ID
 AAB46616.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83979.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83980.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83981.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; AAB83983.1; ABN79590.1; BAD92357.1; AAC15784.1; AAC05808.1 
Protein Name
 Multidrug resistance-associated protein 1 
Protein Synonyms/Alias
 ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter 
Gene Name
 ABCC1 
Gene Synonyms/Alias
 MRP; MRP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
72IQMTPLNKTKTALGFubiquitination[1]
246SDLWSLNKEDTSEQVubiquitination[1]
259QVVPVLVKNWKKECAubiquitination[1]
280VKVVYSSKDPAQPKEubiquitination[1]
290AQPKESSKVDANEEVubiquitination[1]
303EVEALIVKSPQKEWNubiquitination[1]
416VITNSARKSSTVGEIubiquitination[1]
496TYQVAHMKSKDNRIKubiquitination[1]
503KSKDNRIKLMNEILNubiquitination[1]
525YAWELAFKDKVLAIRubiquitination[1]
636SIERRPVKDGGGTNSubiquitination[1]
755FENVIGPKGMLKNKTubiquitination[1]
832TGVSGPGKEAKQMENubiquitination[1]
835SGPGKEAKQMENGMLubiquitination[1]
849LVTDSAGKQLQRQLSubiquitination[1]
877NSTAELQKAEAKKEEubiquitination[1]
1019NLVNRFSKELDTVDSubiquitination[1]
1122FIHQSDLKVDENQKAubiquitination[1]
1128LKVDENQKAYYPSIVubiquitination[1]
1206IVAVERLKEYSETEKubiquitination[1]
1213KEYSETEKEAPWQIQubiquitination[1]
1274VGRTGAGKSSLTLGLubiquitination[1]
1310GLHDLRFKITIIPQDubiquitination[1]
1443TRVIVLDKGEIQEYGubiquitination[1, 2]
1467GLFYSMAKDAGLV**ubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
 Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. 
Sequence Annotation
 DOMAIN 325 608 ABC transmembrane type-1 1.
 DOMAIN 644 868 ABC transporter 1.
 DOMAIN 975 1256 ABC transmembrane type-1 2.
 DOMAIN 1293 1527 ABC transporter 2.
 NP_BIND 678 685 ATP 1.
 NP_BIND 1327 1334 ATP 2 (Potential).
 BINDING 653 653 ATP 1.
 BINDING 713 713 ATP 1.
 MOD_RES 905 905 Phosphoserine.
 MOD_RES 915 915 Phosphoserine.
 MOD_RES 930 930 Phosphoserine.
 CARBOHYD 19 19 N-linked (GlcNAc...).
 CARBOHYD 23 23 N-linked (GlcNAc...).
 CARBOHYD 1006 1006 N-linked (GlcNAc...).  
Keyword
 3D-structure; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Glycoprotein; Hydrolase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1531 AA 
Protein Sequence
MALRGFCSAD GSDPLWDWNV TWNTSNPDFT KCFQNTVLVW VPCFYLWACF PFYFLYLSRH 60
DRGYIQMTPL NKTKTALGFL LWIVCWADLF YSFWERSRGI FLAPVFLVSP TLLGITMLLA 120
TFLIQLERRK GVQSSGIMLT FWLVALVCAL AILRSKIMTA LKEDAQVDLF RDITFYVYFS 180
LLLIQLVLSC FSDRSPLFSE TIHDPNPCPE SSASFLSRIT FWWITGLIVR GYRQPLEGSD 240
LWSLNKEDTS EQVVPVLVKN WKKECAKTRK QPVKVVYSSK DPAQPKESSK VDANEEVEAL 300
IVKSPQKEWN PSLFKVLYKT FGPYFLMSFF FKAIHDLMMF SGPQILKLLI KFVNDTKAPD 360
WQGYFYTVLL FVTACLQTLV LHQYFHICFV SGMRIKTAVI GAVYRKALVI TNSARKSSTV 420
GEIVNLMSVD AQRFMDLATY INMIWSAPLQ VILALYLLWL NLGPSVLAGV AVMVLMVPVN 480
AVMAMKTKTY QVAHMKSKDN RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK 540
KSAYLSAVGT FTWVCTPFLV ALCTFAVYVT IDENNILDAQ TAFVSLALFN ILRFPLNILP 600
MVISSIVQAS VSLKRLRIFL SHEELEPDSI ERRPVKDGGG TNSITVRNAT FTWARSDPPT 660
LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG HVAIKGVNLS GGQKQRVSLA 720
RAVYSNADIY LFDDPLSAVD AHVGKHIFEN VIGPKGMLKN KTRILVTHSM SYLPQVDVII 780
VMSGGKISEM GSYQELLARD GAFAEFLRTY ASTEQEQDAE ENGVTGVSGP GKEAKQMENG 840
MLVTDSAGKQ LQRQLSSSSS YSGDISRHHN STAELQKAEA KKEETWKLME ADKAQTGQVK 900
LSVYWDYMKA IGLFISFLSI FLFMCNHVSA LASNYWLSLW TDDPIVNGTQ EHTKVRLSVY 960
GALGISQGIA VFGYSMAVSI GGILASRCLH VDLLHSILRS PMSFFERTPS GNLVNRFSKE 1020
LDTVDSMIPE VIKMFMGSLF NVIGACIVIL LATPIAAIII PPLGLIYFFV QRFYVASSRQ 1080
LKRLESVSRS PVYSHFNETL LGVSVIRAFE EQERFIHQSD LKVDENQKAY YPSIVANRWL 1140
AVRLECVGNC IVLFAALFAV ISRHSLSAGL VGLSVSYSLQ VTTYLNWLVR MSSEMETNIV 1200
AVERLKEYSE TEKEAPWQIQ ETAPPSSWPQ VGRVEFRNYC LRYREDLDFV LRHINVTING 1260
GEKVGIVGRT GAGKSSLTLG LFRINESAEG EIIIDGINIA KIGLHDLRFK ITIIPQDPVL 1320
FSGSLRMNLD PFSQYSDEEV WTSLELAHLK DFVSALPDKL DHECAEGGEN LSVGQRQLVC 1380
LARALLRKTK ILVLDEATAA VDLETDDLIQ STIRTQFEDC TVLTIAHRLN TIMDYTRVIV 1440
LDKGEIQEYG APSDLLQQRG LFYSMAKDAG LV 1472 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005524; F:ATP binding; TAS:ProtInc.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; TAS:ProtInc.
 GO:0019369; P:arachidonic acid metabolic process; TAS:Reactome.
 GO:0006691; P:leukotriene metabolic process; TAS:Reactome.
 GO:0042493; P:response to drug; TAS:ProtInc. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR005292; Multidrug-R_assoc.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS