CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011805
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 26S proteasome regulatory subunit RPN5 
Protein Synonyms/Alias
 Proteasome non-ATPase subunit 5 
Gene Name
 RPN5 
Gene Synonyms/Alias
 NAS5; YDL147W; D1572 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
71DLLASRNKWDDLNEQacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. 
Sequence Annotation
 DOMAIN 231 404 PCI.
 MOD_RES 2 2 N-acetylserine.  
Keyword
 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Proteasome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 445 AA 
Protein Sequence
MSRDAPIKAD KDYSQILKEE FPKIDSLAQN DCNSALDQLL VLEKKTRQAS DLASSKEVLA 60
KIVDLLASRN KWDDLNEQLT LLSKKHGQLK LSIQYMIQKV MEYLKSSKSL DLNTRISVIE 120
TIRVVTENKI FVEVERARVT KDLVEIKKEE GKIDEAADIL CELQVETYGS MEMSEKIQFI 180
LEQMELSILK GDYSQATVLS RKILKKTFKN PKYESLKLEY YNLLVKISLH KREYLEVAQY 240
LQEIYQTDAI KSDEAKWKPV LSHIVYFLVL SPYGNLQNDL IHKIQNDNNL KKLESQESLV 300
KLFTTNELMR WPIVQKTYEP VLNEDDLAFG GEANKHHWED LQKRVIEHNL RVISEYYSRI 360
TLLRLNELLD LTESQTETYI SDLVNQGIIY AKVNRPAKIV NFEKPKNSSQ LLNEWSHNVD 420
ELLEHIETIG HLITKEEIMH GLQAK 445 
Gene Ontology
 GO:0008541; C:proteasome regulatory particle, lid subcomplex; IDA:SGD.
 GO:0034515; C:proteasome storage granule; IDA:SGD.
 GO:0008180; C:signalosome; IDA:SGD.
 GO:0010388; P:cullin deneddylation; IMP:SGD.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:SGD. 
Interpro
 IPR000717; PCI_dom.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF01399; PCI 
SMART
 SM00088; PINT 
PROSITE
  
PRINTS