CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016129
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin repeat and FYVE domain-containing protein 1 
Protein Synonyms/Alias
 Ankyrin repeats hooked to a zinc finger motif 
Gene Name
 Ankfy1 
Gene Synonyms/Alias
 Ankhzn; Kiaa1255 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
279ATTLVSHKADVDMVDubiquitination[1]
636AIQRQDSKSALFLLEubiquitination[1]
851AMTYKNNKAAEAILKubiquitination[1]
858KAAEAILKRESGAAEubiquitination[1]
931NLLLAGAKVNELTKHubiquitination[1]
937AKVNELTKHRQTALHacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
 DOMAIN 68 130 BTB.
 REPEAT 217 247 ANK 1.
 REPEAT 255 284 ANK 2.
 REPEAT 288 317 ANK 3.
 REPEAT 322 362 ANK 4.
 REPEAT 366 396 ANK 5.
 REPEAT 490 519 ANK 6.
 REPEAT 542 572 ANK 7.
 REPEAT 588 617 ANK 8.
 REPEAT 621 650 ANK 9.
 REPEAT 654 683 ANK 10.
 REPEAT 687 716 ANK 11.
 REPEAT 724 753 ANK 12.
 REPEAT 769 798 ANK 13.
 REPEAT 802 832 ANK 14.
 REPEAT 836 865 ANK 15.
 REPEAT 870 899 ANK 16.
 REPEAT 905 934 ANK 17.
 REPEAT 938 967 ANK 18.
 REPEAT 971 1001 ANK 19.
 REPEAT 1005 1037 ANK 20.
 REPEAT 1043 1072 ANK 21.
 ZN_FING 1104 1164 FYVE-type.
 MOD_RES 2 2 N-acetylalanine (By similarity).  
Keyword
 Acetylation; Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Endosome; Membrane; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1169 AA 
Protein Sequence
MAEEEVAKLE KHLMLLRQEY VKLQKKLAET EKRCTLLAAQ ANKENSNESF ISRLLAIVAG 60
LYEQEQYSDL KIKVGDRHIS AHKFVLAARS DSWSLANLSS TEEIDLSDAN PEVTMTMLRW 120
IYTDELEFRE DDVFLTELMK LANRFQLQLL RERCEKGVMS LVNVRNCIRF YQTAEELNAS 180
TLMNYCAEII ASHWDDLRKE DFSSLSAQLL YKMIKSKTEY PLHKAIKVER EDVVFLYLIE 240
MDSQLPGKLN ETDHNGDLAL DLALSRRLES IATTLVSHKA DVDMVDKNGW SLLHKGIQRG 300
DLFASTFLIK NGALVNAATA GAQETPLHLV ALYSPKKYSA DVMSEMAQIA EALLQAGANP 360
NMQDSKGRTP LHLSIMARND CVFSQLLQCK QLDLELKDHE GSTALWLAVQ YITVSSDQSV 420
NPFEDLPVVN GTSFDENSFA ARLIQRGSNT DAPDVMTGNC LLQRAAGAGN EAAALFLATS 480
GAHANHRNKW GETPLHTACR HGLANLTAEL LQQGANPNLQ TEEALPVPKE SPVLMSSADS 540
IYLQTPLHMA IAYNHPDVVS VILEQKANAL HATNNLQIIP DFSLKDSRDQ TVLGLALWTG 600
MHTIAAQLLG SGASINDTMS DGQTLLHMAI QRQDSKSALF LLEHQADINV RTQDGETALQ 660
LAIKHQLPLV VDAICTRGAD MSVPDEKGNP PLWLALASNL EDIASTLVRH GCDATCWGPG 720
PSGCLQTLLH RAVDENNEST ACFLIRSGCD VNSPRQPGTN GEGEEEARDG QTPLHLAASW 780
GLEETVQCLL EFGANVNAQD AEGRTPVHVA ISNQHSVIIQ LLISHPNIEL SVRDRQGLTP 840
FACAMTYKNN KAAEAILKRE SGAAEQVDNK GRNFLHVAVQ NSDIESVLFL ISVQANVNSR 900
VQDASKLTPL HLAVQAGSEI IVRNLLLAGA KVNELTKHRQ TALHLAAQQD LPTICSVLLE 960
NGVDFAAVDE NGNNALHLAV MHGRLNNIRA LLTECTVDAE AFNLRGQSPL HILGQYGKEN 1020
AAAIFDLFLE CMPEYPLDKP DAEGNTVLLL AYMKGNANLC RAIVRSGVRL GVNNNQGVNI 1080
FNYQVATKQL LFRLLDMLSK EPPWCDGSNC YECTAKFGVT TRKHHCRHCG RLLCHKCSTK 1140
EIPIIKFDLN KPVRVCNICF DVLTLGGVS 1169 
Gene Ontology
 GO:0010008; C:endosome membrane; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006897; P:endocytosis; NAS:UniProtKB. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF12796; Ank_2
 PF00651; BTB
 PF01363; FYVE 
SMART
 SM00248; ANK
 SM00225; BTB
 SM00064; FYVE 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50097; BTB
 PS50178; ZF_FYVE 
PRINTS
 PR01415; ANKYRIN.