| Tag | Content |
|---|
| CPLM ID | CPLM-020137 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein canopy homolog 3 |
Protein Synonyms/Alias | CTG repeat protein 4a; Expanded repeat-domain protein CAG/CTG 5; Protein associated with TLR4; Trinucleotide repeat-containing gene 5 protein |
Gene Name | CNPY3 |
Gene Synonyms/Alias | CTG4A; ERDA5; PRAT4A; TNRC5; HSPC084; UNQ1934/PRO4409 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 114 | LLDYSLHKERTGSNR | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptative immune responses (By similarity). |
Sequence Annotation | DOMAIN 47 271 Saposin B-type.
CARBOHYD 153 153 N-linked (GlcNAc...).
DISULFID 49 206 By similarity.
DISULFID 52 194 By similarity.
DISULFID 104 166 By similarity. |
Keyword | Alternative splicing; Chaperone; Coiled coil; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Immunity; Innate immunity; Polymorphism; Reference proteome; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 278 AA |
Protein Sequence | MDSMPEPASR CLLLLPLLLL LLLLLPAPEL GPSQAGAEEN DWVRLPSKCE VCKYVAVELK 60
SAFEETGKTK EVIGTGYGIL DQKASGVKYT KSDLRLIEVT ETICKRLLDY SLHKERTGSN 120
RFAKGMSETF ETLHNLVHKG VKVVMDIPYE LWNETSAEVA DLKKQCDVLV EEFEEVIEDW 180
YRNHQEEDLT EFLCANHVLK GKDTSCLAEQ WSGKKGDTAA LGGKKSKKKS SRAKAAGGRS 240
SSSKQRKELG GLEGDPSPEE DEGIQKASPL THSPPDEL 278 |
Gene Ontology | GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome. GO:0045087; P:innate immune response; TAS:Reactome. GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome. |
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PROSITE | |
PRINTS | |