UniProt Accession

 GPDA_ECOLI; P0A6S7; P37606; Q2M7S2 

Genbank Protein ID

 U00039; U00096; AP009048 

Genbank Nucleotide ID

 AAB18585.1; AAC76632.1; BAE77684.1 

Protein Name

 Glycerol-3-phosphate dehydrogenase [NAD(P)+] 

Protein Synonyms/Alias

 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 

Gene Name

 gpsA 

Gene Synonyms/Alias

 b3608; JW3583 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
175	QQLLHCGKSFRVYSN	acetylation	[1]
279	DVQSAQEKIGQVVEG	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

  

Sequence Annotation

 NP_BIND 12 17 NAD (By similarity).
 REGION 259 260 Substrate binding (By similarity).
 ACT_SITE 195 195 Proton acceptor (By similarity).
 BINDING 110 110 NAD; via amide nitrogen (By similarity).
 BINDING 110 110 Substrate (By similarity).
 BINDING 143 143 NAD; via amide nitrogen (By similarity).
 BINDING 259 259 NAD (By similarity).
 BINDING 285 285 NAD (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Lipid biosynthesis; Lipid metabolism; NAD; Oxidoreductase; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 339 AA 

Protein Sequence

Gene Ontology

 GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
 GO:0047952; F:glycerol-3-phosphate dehydrogenase [NAD(P)+] activity; IDA:EcoCyc.
 GO:0004367; F:glycerol-3-phosphate dehydrogenase [NAD+] activity; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
 GO:0046167; P:glycerol-3-phosphate biosynthetic process; IEA:HAMAP.
 GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro.
 GO:0046474; P:glycerophospholipid biosynthetic process; IMP:EcoCyc. 

Interpro

 IPR008927; 6-PGluconate_DH_C-like.
 IPR013328; DH_multihelical.
 IPR006168; G3P_DH_NAD-dep.
 IPR006109; G3P_DH_NAD-dep_C.
 IPR011128; G3P_DH_NAD-dep_N.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF07479; NAD_Gly3P_dh_C
 PF01210; NAD_Gly3P_dh_N 

SMART

  

PROSITE

 PS00957; NAD_G3PDH 

PRINTS

 PR00077; GPDHDRGNASE.