UniProt Accession

 RRMJ2_HUMAN; Q9UI43; Q24JR8 

Genbank Protein ID

 AF093415; BC114514 

Genbank Nucleotide ID

 AAF22488.1; AAI14515.1 

Protein Name

 Putative ribosomal RNA methyltransferase 2 

Protein Synonyms/Alias

 Protein ftsJ homolog 2; rRNA (uridine-2'-O-)-methyltransferase 

Gene Name

 FTSJ2 

Gene Synonyms/Alias

 FJH1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
45	HLRDPFVKAAKVESY	ubiquitination	[1, 2, 3]
48	DPFVKAAKVESYRCR	ubiquitination	[1, 2, 3]
59	YRCRSAFKLLEVNER	ubiquitination	[1, 3]
219	FQNVRIIKPEASRKE	ubiquitination	[4]
225	IKPEASRKESSEVYF	ubiquitination	[1, 2, 3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Probable methyltransferase. 

Sequence Annotation

 REGION 83 86 S-adenosyl-L-methionine binding.
 REGION 129 130 S-adenosyl-L-methionine binding.
 BINDING 56 56 S-adenosyl-L-methionine.
 BINDING 112 112 S-adenosyl-L-methionine.
 BINDING 154 154 S-adenosyl-L-methionine.  

Keyword

 3D-structure; Complete proteome; Methyltransferase; Nucleus; Reference proteome; rRNA processing; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; ISS:BHF-UCL.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0008650; F:rRNA (uridine-2'-O-)-methyltransferase activity; NAS:BHF-UCL.
 GO:0008283; P:cell proliferation; NAS:BHF-UCL. 

Interpro

 IPR015507; rRNA-MeTfrase_E.
 IPR002877; rRNA_MeTrfase_FtsJ_dom. 

Pfam

 PF01728; FtsJ 

SMART

  

PROSITE

  

PRINTS