CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040419
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Ech1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
5***QKISKDSDCRAVacetylation[1]
80ELTFSARKMMADEALacetylation[2]
80ELTFSARKMMADEALsuccinylation[2]
80ELTFSARKMMADEALubiquitination[3]
125PVAVQGSKINLIYSRubiquitination[3]
166SVQAAMEKRDTKSITacetylation[1, 2, 4]
166SVQAAMEKRDTKSITsuccinylation[2]
176TKSITFSKL******acetylation[1, 5]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 177 AA 
Protein Sequence
QKISKDSDCR AVVVSGAGKM FTSGVDLVSA CDIRYCTQDA FFQIKEVDMG LAADVGTLQR 60
LPKVIGNQSL VNELTFSARK MMADEALDSG LVSRVFQDKD AMLNAAFALA ADISSKSPVA 120
VQGSKINLIY SRDHSVDESL DYMATWNMSM LQTQDIIKSV QAAMEKRDTK SITFSKL 177 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0003824; F:catalytic activity; IEA:InterPro. 
Interpro
 IPR014748; Crontonase_C.
 IPR001753; Crotonase_core_superfam. 
Pfam
 PF00378; ECH 
SMART
  
PROSITE
  
PRINTS