CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030743
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Battenin 
Protein Synonyms/Alias
 Ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease), isoform CRA_d; cDNA FLJ60087, highly similar to Protein CLN3 
Gene Name
 CLN3 
Gene Synonyms/Alias
 hCG_1745226 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
208RTEAPESKPGSSSSLubiquitination[1, 2, 3, 4, 5, 6, 7]
Reference
 [1] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 384 AA 
Protein Sequence
MLSAAHDILS HKRTSGNQSH VDPGPTPIPH NSSSRFDCNS VSTAAVLLAD ILPTLVIKLL 60
APLGLHLLPY SPRVLVSGIC AAGSFVLVAF SHSVGTSLCG VVFASISSGL GEVTFLSLTA 120
FYPRAVISWW SSGTGGAGLL GALSYLGLTQ AGLSPQQTLL SMLGIPALLL ASYFLLLTSP 180
EAQDPGGEEE AESAARQPLI RTEAPESKPG SSSSLSLRER WTVFKGLLWY IVPLVVVYFA 240
EYFINQGLFE LLFFWNTSLS HAQQYRWYQM LYQAGVFASR SSLRCCRIRF TWALALLQCL 300
NLVFLLADVW FGFLPSIYLV FLIILYEGLL GGAAYVNTFH NIALETSDEH REFAMAATCI 360
SDTLGISLSG LLALPLHDFL CQLS 384 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro. 
Interpro
 IPR003492; Battenin_disease_Cln3.
 IPR018460; Battenin_disease_Cln3_subgr.
 IPR016196; MFS_dom_general_subst_transpt. 
Pfam
 PF02487; CLN3 
SMART
  
PROSITE
  
PRINTS
 PR01315; BATTENIN.