| Tag | Content |
|---|
| CPLM ID | CPLM-014540 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Hsp90 co-chaperone Cdc37 |
Protein Synonyms/Alias | Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed |
Gene Name | Cdc37 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 155 | KHKTFVEKYEKQIKH | acetylation | [1] | | 158 | TFVEKYEKQIKHFGM | acetylation | [1] | | 161 | EKYEKQIKHFGMLHR | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. |
Sequence Annotation | MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 2 2 N-acetylvaline; in Hsp90 co-chaperone
MOD_RES 13 13 Phosphoserine (By similarity).
MOD_RES 155 155 N6-acetyllysine (By similarity).
MOD_RES 378 378 Phosphoserine (By similarity). |
Keyword | Acetylation; Chaperone; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 379 AA |
Protein Sequence | MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK 60
VAECQRKLKE LEVAEGGGQV ELERLRAEAQ QLRKEERSWE QKLEDMRKKE KNMPWNVDTL 120
SKDGFSKSMV NTKPEKAEED SEEAREQKHK TFVEKYEKQI KHFGMLHRWD DSQKYLSDNV 180
HLVCEETANY LVIWCIDLEV EEKCALMEQV AHQTMVMQFI LELAKSLKVD PRACFRQFFT 240
KIKTADQQYM EGFKYELEAF KERVRGRAKL RIEKAMKEYE EEERKKRLGP GGLDPVEVYE 300
SLPEELQKCF DVKDVQMLQD AISKMDPTDA KYHMQRCIDS GLWVPNSKSG EAKEGEEAGP 360
GDPLLEAVPK AGNEKDISA 379 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:RGD. GO:0005829; C:cytosol; IEA:Compara. GO:0043234; C:protein complex; IDA:RGD. GO:0032587; C:ruffle membrane; IDA:RGD. GO:0051726; P:regulation of cell cycle; IEP:RGD. GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; IEA:Compara. GO:0060338; P:regulation of type I interferon-mediated signaling pathway; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |