CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003565
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dihydrofolate reductase FolM 
Protein Synonyms/Alias
 DHFR 
Gene Name
 folM 
Gene Synonyms/Alias
 ydgB; b1606; JW1598 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
148VVERGSDKHIAYAASacetylation[1]
201YRQQALNKSLMKTAPacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the reduction of dihydrofolate to tetrahydrofolate. 
Sequence Annotation
 ACT_SITE 152 152 Proton acceptor (By similarity).  
Keyword
 Complete proteome; NADP; One-carbon metabolism; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 240 AA 
Protein Sequence
MGKTQPLPIL ITGGGRRIGL ALAWHFINQK QPVIVSYRTH YPAIDGLINA GAQCIQADFS 60
TNDGVMAFAD EVLKSTHGLR AILHNASAWM AEKPGAPLAD VLACMMQIHV NTPYLLNHAL 120
ERLLRGHGHA ASDIIHFTDY VVERGSDKHI AYAASKAALD NMTRSFARKL APEVKVNSIA 180
PSLILFNEHD DAEYRQQALN KSLMKTAPGE KEVIDLVDYL LTSCFVTGRS FPLDGGRHLR 240 
Gene Ontology
 GO:0004146; F:dihydrofolate reductase activity; IEA:EC.
 GO:0071172; F:dihydromonapterin reductase activity; IDA:EcoCyc.
 GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; IGI:EcoCyc.
 GO:0046656; P:folic acid biosynthetic process; IGI:EcoCyc.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.