UniProt Accession

 1433G_MOUSE; P61982; O70457; P35214; Q3UFD6; Q4FK44; Q9UDP2; Q9UN99 

Genbank Protein ID

 AF058799; CT010208; AK088847; AK148618; AK153307; AK164356; BC008129 

Genbank Nucleotide ID

 AAC14345.1; CAJ18416.1; BAC40609.1; BAE28625.1; BAE31888.1; BAE37756.1; AAH08129.1 

Protein Name

 14-3-3 protein gamma 

Protein Synonyms/Alias

 14-3-3 protein gamma, N-terminally processed 

Gene Name

 Ywhag 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
10	DREQLVQKARLAEQA	acetylation	[1]
10	DREQLVQKARLAEQA	ubiquitination	[2]
28	DDMAAAMKNVTELNE	ubiquitination	[2]
69	VISSIEQKTSADGNE	ubiquitination	[2]
77	TSADGNEKKIEMVRA	ubiquitination	[2]
120	SETQYESKVFYLKMK	acetylation	[3]
120	SETQYESKVFYLKMK	ubiquitination	[2]
142	AEVATGEKRATVVES	ubiquitination	[2]
152	TVVESSEKAYSEAHE	ubiquitination	[2]
162	SEAHEISKEHMQPTH	acetylation	[4]
162	SEAHEISKEHMQPTH	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599] 

Functional Description

 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylvaline; in 14-3-3 protein gamma,
 MOD_RES 117 117 Phosphotyrosine.
 MOD_RES 145 145 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 247 AA 

Protein Sequence

Gene Ontology

 GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0003779; F:actin binding; ISS:UniProtKB.
 GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
 GO:0019904; F:protein domain specific binding; IDA:MGI.
 GO:0005080; F:protein kinase C binding; ISS:UniProtKB.
 GO:0006605; P:protein targeting; IDA:MGI.
 GO:0045664; P:regulation of neuron differentiation; ISS:UniProtKB.
 GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1
 PS00797; 1433_2 

PRINTS

 PR00305; 1433ZETA.