UniProt Accession

 RPC9_HUMAN; O75575; A8MUZ4; A8MW23; B2R4H4; B4E198; Q3KRA3; Q5HYF1; Q8IXL4 

Genbank Protein ID

 AF073792; U51134; AK290553; AK303737; AK311829; BP233211; BX647867; AC068533; CH471140; BC040107; BC105808 

Genbank Nucleotide ID

 AAC25992.1; AAD05036.1; BAF83242.1; BAG64710.1; BAG34771.1; CAI46069.1; EAX07941.1; AAH40107.1; AAI05809.1 

Protein Name

 DNA-directed RNA polymerase III subunit RPC9 

Protein Synonyms/Alias

 RNA polymerase III subunit C9; Calcitonin gene-related peptide-receptor component protein; CGRP-RCP; CGRP-receptor component protein; CGRPRCP; HsC17 

Gene Name

 CRCP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	TITYETLKYISKTPC	acetylation	[1]
134	EPEAEQKKNTNSNVA	ubiquitination	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa- B through the RIG-I pathway (By similarity). 

Sequence Annotation

  

Keyword

 Alternative splicing; Antiviral defense; Cell membrane; Complete proteome; DNA-directed RNA polymerase; Immunity; Innate immunity; Membrane; Nucleus; Reference proteome; Transcription. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 148 AA 

Protein Sequence

Gene Ontology

 GO:0001669; C:acrosomal vesicle; IEA:Compara.
 GO:0009360; C:DNA polymerase III complex; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0001635; F:calcitonin gene-related polypeptide receptor activity; IEA:Compara.
 GO:0004948; F:calcitonin receptor activity; NAS:UniProtKB.
 GO:0003899; F:DNA-directed RNA polymerase activity; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0007340; P:acrosome reaction; NAS:UniProtKB.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0007218; P:neuropeptide signaling pathway; IEA:Compara.
 GO:0006383; P:transcription from RNA polymerase III promoter; IDA:UniProtKB. 

Interpro

 IPR010997; HRDC-like.
 IPR005574; RNA_pol_II_Rpb4.
 IPR006590; RNA_pol_II_Rpb4_core. 

Pfam

 PF03874; RNA_pol_Rpb4 

SMART

 SM00657; RPOL4c 

PROSITE

  

PRINTS