CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002754
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dopamine beta-hydroxylase 
Protein Synonyms/Alias
 Dopamine beta-monooxygenase; Soluble dopamine beta-hydroxylase 
Gene Name
 DBH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
82QLLVRRLKAGVLFGMubiquitination[1]
248FSRHHIIKYEPIVTKubiquitination[1]
616VVSIGGGKG******ubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Conversion of dopamine to noradrenaline. 
Sequence Annotation
 DOMAIN 57 173 DOMON.
 ACT_SITE 230 230 Potential.
 ACT_SITE 412 412 Potential.
 METAL 262 262 Copper A (By similarity).
 METAL 263 263 Copper A (By similarity).
 METAL 333 333 Copper A (By similarity).
 METAL 412 412 Copper B (By similarity).
 METAL 414 414 Copper B (By similarity).
 METAL 487 487 Copper B (By similarity).
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 184 184 N-linked (GlcNAc...).
 DISULFID 154 596 By similarity.
 DISULFID 232 283 By similarity.
 DISULFID 269 295 By similarity.
 DISULFID 390 503 By similarity.
 DISULFID 394 565 By similarity.
 DISULFID 466 488 By similarity.
 DISULFID 528 528 Interchain (By similarity).
 DISULFID 530 530 Interchain (By similarity).  
Keyword
 Catecholamine biosynthesis; Complete proteome; Copper; Cytoplasmic vesicle; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Membrane; Metal-binding; Monooxygenase; Oxidoreductase; Polymorphism; PQQ; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix; Vitamin C. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 617 AA 
Protein Sequence
MPALSRWASL PGPSMREAAF MYSTAVAIFL VILVAALQGS APRESPLPYH IPLDPEGSLE 60
LSWNVSYTQE AIHFQLLVRR LKAGVLFGMS DRGELENADL VVLWTDGDTA YFADAWSDQK 120
GQIHLDPQQD YQLLQVQRTP EGLTLLFKRP FGTCDPKDYL IEDGTVHLVY GILEEPFRSL 180
EAINGSGLQM GLQRVQLLKP NIPEPELPSD ACTMEVQAPN IQIPSQETTY WCYIKELPKG 240
FSRHHIIKYE PIVTKGNEAL VHHMEVFQCA PEMDSVPHFS GPCDSKMKPD RLNYCRHVLA 300
AWALGAKAFY YPEEAGLAFG GPGSSRYLRL EVHYHNPLVI EGRNDSSGIR LYYTAKLRRF 360
NAGIMELGLV YTPVMAIPPR ETAFILTGYC TDKCTQLALP PSGIHIFASQ LHTHLTGRKV 420
VTVLVRDGRE WEIVNQDNHY SPHFQEIRML KKVVSVHPGD VLITSCTYNT EDRELATVGG 480
FGILEEMCVN YVHYYPQTQL ELCKSAVDAG FLQKYFHLIN RFNNEDVCTC PQASVSQQFT 540
SVPWNSFNRD VLKALYSFAP ISMHCNKSSA VRFQGEWNLQ PLPKVISTLE EPTPQCPTSQ 600
GRSPAGPTVV SIGGGKG 617 
Gene Ontology
 GO:0042583; C:chromaffin granule; NAS:UniProtKB.
 GO:0034466; C:chromaffin granule lumen; IEA:UniProtKB-SubCell.
 GO:0042584; C:chromaffin granule membrane; IEA:UniProtKB-SubCell.
 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; TAS:ProtInc.
 GO:0034774; C:secretory granule lumen; TAS:Reactome.
 GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005507; F:copper ion binding; IEA:InterPro.
 GO:0004500; F:dopamine beta-monooxygenase activity; TAS:Reactome.
 GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
 GO:0048149; P:behavioral response to ethanol; IEA:Compara.
 GO:0001974; P:blood vessel remodeling; IEA:Compara.
 GO:0042423; P:catecholamine biosynthetic process; TAS:Reactome.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0001816; P:cytokine production; IEA:Compara.
 GO:0042420; P:dopamine catabolic process; IEA:Compara.
 GO:0042596; P:fear response; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0042309; P:homoiothermy; IEA:Compara.
 GO:0002443; P:leukocyte mediated immunity; IEA:Compara.
 GO:0050900; P:leukocyte migration; IEA:Compara.
 GO:0007626; P:locomotory behavior; IEA:Compara.
 GO:0042711; P:maternal behavior; IEA:Compara.
 GO:0007613; P:memory; IEA:Compara.
 GO:0042421; P:norepinephrine biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0045907; P:positive regulation of vasoconstriction; IEA:Compara.
 GO:0042981; P:regulation of apoptotic process; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0048265; P:response to pain; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0007268; P:synaptic transmission; TAS:ProtInc.
 GO:0008542; P:visual learning; IEA:Compara. 
Interpro
 IPR014784; Cu2_ascorb_mOase-like_C.
 IPR020611; Cu2_ascorb_mOase_CS-1.
 IPR014783; Cu2_ascorb_mOase_CS-2.
 IPR000323; Cu2_ascorb_mOase_N.
 IPR005018; DOMON_domain.
 IPR000945; Dopamine_b_mOase.
 IPR008977; PHM/PNGase_F_dom. 
Pfam
 PF01082; Cu2_monooxygen
 PF03351; DOMON 
SMART
 SM00664; DoH 
PROSITE
 PS00084; CU2_MONOOXYGENASE_1
 PS00085; CU2_MONOOXYGENASE_2
 PS50836; DOMON 
PRINTS
 PR00767; DBMONOXGNASE.