UniProt Accession

 F16P1_MOUSE; Q9QXD6; Q3UEH1 

Genbank Protein ID

 AJ132693; AK002216; AK149527; BC011480; BC051392 

Genbank Nucleotide ID

 CAB65244.1; BAB21941.1; BAE28940.1; AAH11480.1; AAH51392.1 

Protein Name

 Fructose-1,6-bisphosphatase 1 

Protein Synonyms/Alias

 FBPase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 

Gene Name

 Fbp1 

Gene Synonyms/Alias

 Fbp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	FVMEQGRKAQGTGEL	ubiquitination	[1]
72	NVTGDQVKKLDILSN	ubiquitination	[1]
73	VTGDQVKKLDILSND	ubiquitination	[1]
143	IFGIYRKKSTDEPSE	acetylation	[2]
151	STDEPSEKDALQPGR	acetylation	[2]
151	STDEPSEKDALQPGR	ubiquitination	[1]
206	RDVKMKKKGNIYSLN	ubiquitination	[1]
218	SLNEGYAKDFDPAIN	acetylation	[3]
218	SLNEGYAKDFDPAIN	ubiquitination	[1]
269	IFLYPANKKSPSGKL	ubiquitination	[1]
301	GLATTGDKDILDIVP	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

  

Sequence Annotation

 NP_BIND 18 22 AMP (By similarity).
 NP_BIND 28 32 AMP (By similarity).
 NP_BIND 113 114 AMP (By similarity).
 REGION 122 125 Substrate binding (By similarity).
 REGION 213 216 Substrate binding (By similarity).
 REGION 244 249 Substrate binding (By similarity).
 REGION 275 277 Substrate binding (By similarity).
 METAL 69 69 Magnesium 1 (By similarity).
 METAL 98 98 Magnesium 1 (By similarity).
 METAL 98 98 Magnesium 2 (By similarity).
 METAL 119 119 Magnesium 2 (By similarity).
 METAL 119 119 Magnesium 3 (By similarity).
 METAL 121 121 Magnesium 2; via carbonyl oxygen (By
 METAL 122 122 Magnesium 3 (By similarity).
 METAL 281 281 Magnesium 3 (By similarity).
 BINDING 141 141 AMP (By similarity).
 BINDING 265 265 Substrate (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Allosteric enzyme; Carbohydrate metabolism; Complete proteome; Gluconeogenesis; Hydrolase; Magnesium; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 338 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0016208; F:AMP binding; ISS:UniProtKB.
 GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; ISS:UniProtKB.
 GO:0048029; F:monosaccharide binding; ISS:UniProtKB.
 GO:0035690; P:cellular response to drug; ISS:UniProtKB.
 GO:0071286; P:cellular response to magnesium ion; ISS:UniProtKB.
 GO:0006002; P:fructose 6-phosphate metabolic process; ISS:UniProtKB.
 GO:0006094; P:gluconeogenesis; ISS:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
 GO:0045820; P:negative regulation of glycolysis; ISS:UniProtKB.
 GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:UniProtKB.
 GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
 GO:0006111; P:regulation of gluconeogenesis; ISS:UniProtKB. 

Interpro

 IPR000146; FBPase_class-1/SBPase.
 IPR020548; Fructose_bisphosphatase_AS. 

Pfam

 PF00316; FBPase 

SMART

  

PROSITE

 PS00124; FBPASE 

PRINTS

 PR00115; F16BPHPHTASE.