CPLM-009506

Genbank Nucleotide ID

Ras-related protein Rab-11A

Protein Synonyms/Alias

Mus musculus (Mouse)

Position	Peptide	Type	References
179	IYRIVSQKQMSDRRE	ubiquitination	[1]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes.

NP_BIND 18 26 GTP (By similarity).
NP_BIND 66 70 GTP (By similarity).
NP_BIND 124 127 GTP (By similarity).
NP_BIND 154 156 GTP (By similarity).
MOTIF 40 48 Effector region (By similarity).
MOD_RES 2 2 N-acetylglycine (By similarity).
MOD_RES 213 213 Cysteine methyl ester (Potential).
LIPID 212 212 S-geranylgeranyl cysteine (By
LIPID 213 213 S-geranylgeranyl cysteine (By

Acetylation; Cell cycle; Cell membrane; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Endosome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0030424; C:axon; IDA:MGI.
GO:0032154; C:cleavage furrow; ISS:UniProtKB.
GO:0005739; C:mitochondrion; IDA:MGI.
GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0043234; C:protein complex; IEA:Compara.
GO:0055037; C:recycling endosome; IDA:UniProtKB.
GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
GO:0005802; C:trans-Golgi network; ISO:MGI.
GO:0030133; C:transport vesicle; IEA:Compara.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0003924; F:GTPase activity; ISS:UniProtKB.
GO:0000910; P:cytokinesis; IEA:Compara.
GO:0032402; P:melanosome transport; IMP:UniProtKB.
GO:0031175; P:neuron projection development; ISS:UniProtKB.
GO:0045773; P:positive regulation of axon extension; IMP:MGI.
GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Compara.
GO:0051223; P:regulation of protein transport; IEA:Compara.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
GO:0016192; P:vesicle-mediated transport; IEA:Compara.

IPR027417; P-loop_NTPase.
IPR005225; Small_GTP-bd_dom.
IPR001806; Small_GTPase.
IPR003579; Small_GTPase_Rab_type.

PR00449; RASTRNSFRMNG.