CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013394
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA-directed RNA polymerase subunit alpha 
Protein Synonyms/Alias
 RNAP subunit alpha; RNA polymerase subunit alpha; Transcriptase subunit alpha 
Gene Name
 rpoA 
Gene Synonyms/Alias
 MPN_191; MP640 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
3*****MEKFLKYEIKacetylation[1]
6**MEKFLKYEIKVNNacetylation[1]
255ALNIIQEKAEERRVRacetylation[1]
266RRVRSFAKQIEELDFacetylation[1]
316KSEREIIKKVHELGLacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). 
Sequence Annotation
 REGION 1 243 Alpha N-terminal domain (alpha-NTD) (By
 REGION 260 327 Alpha C-terminal domain (alpha-CTD) (By  
Keyword
 Complete proteome; DNA-directed RNA polymerase; Nucleotidyltransferase; Reference proteome; Transcription; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 327 AA 
Protein Sequence
MEKFLKYEIK VNNEQARANP NYGIFEVGPL ESGFVITIGN AMRRVLLSCI PGASVFALSI 60
SGAKQEFAAV EGMKEDVTEV VLNFKQLVVK ISDLLFEDGE MVEPPLERWP LLTVTAEKAG 120
PVYAKDLECP AGFEVVNKDL YLFSLQTDKK VTVNVYVKQG RGFVTFLENR EMINSLGIIA 180
TDSNFSPVLH CGYEVQELKT SKQKITDHLT FKIATNGAIS AVDAFAMAAK ILIEHLNPIV 240
NVNESIKALN IIQEKAEERR VRSFAKQIEE LDFTVRTFNC LKRSGIHTLQ ELLSKSLADI 300
REIRNLGKKS EREIIKKVHE LGLKLRS 327 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:HAMAP.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:HAMAP.
 GO:0006351; P:transcription, DNA-dependent; IEA:HAMAP. 
Interpro
 IPR011261; DNA-dir_RNA_pol_dimersation.
 IPR011262; DNA-dir_RNA_pol_insert.
 IPR009025; DNA-dir_RNA_pol_RBP11-like.
 IPR011263; DNA-dir_RNA_pol_RpoA/D/Rpb3.
 IPR011773; DNA-dir_RpoA.
 IPR011260; RNAP_asu_C. 
Pfam
 PF01000; RNA_pol_A_bac
 PF03118; RNA_pol_A_CTD
 PF01193; RNA_pol_L 
SMART
 SM00662; RPOLD 
PROSITE
  
PRINTS