UniProt Accession

 OMPR_ECOLI; P0AA16; O31133; P03025; P08981; P41405; Q2M770 

Genbank Protein ID

 J01656; U18997; U00096; AP009048 

Genbank Nucleotide ID

 AAA16241.1; AAA58202.1; AAC76430.1; BAE77886.1 

Protein Name

 Transcriptional regulatory protein OmpR 

Protein Synonyms/Alias

  

Gene Name

 ompR 

Gene Synonyms/Alias

 kmt; ompB; b3405; JW3368 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
105	GADDYIPKPFNPREL	acetylation	[1]
142	EAVIAFGKFKLNLGT	acetylation	[1]
144	VIAFGKFKLNLGTRE	acetylation	[1]
170	SGEFAVLKALVSHPR	acetylation	[1]
184	REPLSRDKLMNLARG	acetylation	[1, 2]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 The N-terminus of this protein is required for the transcriptional expression of both major outer membrane protein genes ompF and ompC; its C-terminal moiety mediates the multimerization of the OmpR protein. As a multimer, it turns on the expression of the ompC gene; as a monomer, it turns on the expression of the ompF gene. 

Sequence Annotation

 DOMAIN 1 120 Response regulatory.
 MOD_RES 55 55 4-aspartylphosphate.  

Keyword

 3D-structure; Activator; Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 239 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000156; F:phosphorelay response regulator activity; IDA:EcoliWiki.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:EcoliWiki.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR001867; Sig_transdc_resp-reg_C.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00072; Response_reg
 PF00486; Trans_reg_C 

SMART

 SM00448; REC
 SM00862; Trans_reg_C 

PROSITE

 PS50110; RESPONSE_REGULATORY 

PRINTS