| Tag | Content |
|---|
| CPLM ID | CPLM-039336 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA topoisomerase 2 |
Protein Synonyms/Alias | |
Gene Name | Top2a |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1278 | KQTTLPFKPIKKGKK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (By similarity). |
Sequence Annotation | |
Keyword | ATP-binding; Complete proteome; DNA-binding; Isomerase; Nucleotide-binding; Reference proteome; Topoisomerase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1525 AA |
Protein Sequence | VSPAQPVNEN MLLNKKKNED GKKRLSVERI YQKKTQLEHI LLRPDTYIGS VELVTQQMWV 60
YDEDVGINYR EVTFVPGLYK IFDEILVNAA DNKQRDPKMS CIRVTIGENN LISIWNNGKG 120
IPVVEHKVEK MYVPALIFGQ LLTSSNYDDD EKKVTGGRNG YGAKLCNIFS TKFTVETASR 180
EYKKMFKQTW MDNMGRAGDM ELKPFSGEDY TCITFQPDLS KFKMQSLDKD IVALMVRRAY 240
DIAGSTKDVK VFLNGNRLPV KGFRSYVDMY LKDKVDETGN ALKVVHEQVN PRWEVCLTMS 300
EKGFQQISFV NSIATSKGGR HVDYVADQIV SKLVDVVKKK NKGGVAVKAH QVKNHMWIFV 360
NALIENPTFD SQTKENMTLQ AKSFGSTCQL SEKFIKAAIG CGIVESILNW VKFKAQIQLN 420
KKCSAVKHNR IKGIPKLDDA NDAGSRNSAE CTLILTEGDS AKTLAVSGLG VVGRDKYGVF 480
PLRGKILNVR EASHKQIMEN AEINNIIKIV GLQYKKNYED EDSLKTLRYG KIMIMTDQDQ 540
DGSHIKGLLI NFIHHNWPSL LRHRFLEEFI TPIVKVSKNK QEIAFYSLPE FEEWKSANPN 600
HKKWKVKYYK GLGTSTSKEA KEYFANMKRH RIQFKYSGPE DDAAISLAFS KKQVDDRKEW 660
LTNFMEDRRQ RKLLGLPEDY LYGQTTMYLT YNDFINKELI LFSNSDNERS IPSMVDGLKP 720
GQRKVLFTCF KRNDKREVKV AQLAGSVAEM SSYHHGEMSL MMTIINLAQN FVGSNNLNLL 780
QPIGQFGTRL HGGKDSASPR YIFTMLSPLA RLLFPSKDDH TLRFLYDDNQ RVEPEWYIPI 840
IPMVLINGAE GIGTGWSCKI PNFDVREVVN NIRRLLDGEE PLPMLPSYKN YKGTIEELAS 900
NQYVINGEVA ILNSTTIEIT ELPIRTWTQT YKEQVLEPML NGTEKTPPLI TDYREYHTDT 960
TVKFVIKMTE EKLAEAERVG LHKVFKLQTS LTCNSMVLFD HVGCLKKYDT VLDILRDFFE 1020
LRLKYYGLRK EWLLGMLGAE SSKLNNQARF ILEKIDGKIV IENKPKKELI KVLIQRGYDS 1080
DPVKAWKEAQ QKVPEEEENE ENEESESESS SPAAESGPTF NYLLDMPLWY LTKEKKDELC 1140
KQRDEKEQEL NTLKKKTPSD LWKEDLAAFV EELEVVEAKE KQDEQVGLPG KGVKAKGKKA 1200
QISEVLPSPV GKRVIPQVTM EMRAEAEKKI RRKIKSENVE GTPAEDGAEP GGLRQRLEKR 1260
QKREPGTRAK KQTTLPFKPI KKGKKKNPWS DSESDMSSNE SNFDVPPREK EPRIAATKAK 1320
FTADLDSDDD FSGLDEKDED EDFFPLDDTP PKTKMPPKNT KKALKPQKSS TSVDLESDGK 1380
DSVPASPGAS AADVPAETEP SKPSSKQTVG VKRTITKGQS LTSTAGTKKR AVPKETKSDS 1440
ALNAHVSKKP APAKAKNSRK RKPSSSDSSD SEFEKAISKG ATSKKPKGEE RDFHVDLDDT 1500
VAPRAKSGRA RKPIKYLEES DDDLF 1525 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |