CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030096
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dihydrolipoamide branched chain transacylase E2 
Protein Synonyms/Alias
 Dihydrolipoamide branched chain transacylase E2, isoform CRA_b; Protein Dbt 
Gene Name
 Dbt 
Gene Synonyms/Alias
 rCG_28617 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
82GIREVTIKEWYVKEGacetylation[1]
133DDIAYVGKPLIDIETacetylation[1]
202GKDGRILKEDILNFLacetylation[1]
243PFPTPVSKPPVFLGKacetylation[1]
261EPVTGFQKAMVKTMSacetylation[1]
265GFQKAMVKTMSAALKacetylation[1]
295VKLREELKPVALARGacetylation[1]
304VALARGIKLSFMPFFacetylation[1]
435ALPRFDQKGDVYKAQacetylation[1]
440DQKGDVYKAQIMNVSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Acyltransferase; Complete proteome; Lipoyl; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 482 AA 
Protein Sequence
MAAARVLGTW SRNAVRLTCV RYFQTYNNVH ILKPQHVCSV GYPLLKSSQP RHSLRTAAVL 60
QGQVVQFKLS DIGEGIREVT IKEWYVKEGD TVSQFDSICE VQSDKASVTI TSRYDGVIKR 120
LYYNLDDIAY VGKPLIDIET EALKDSEEDV VETPAVAHDE HTHQEIKGQK TLATPAVRRL 180
AMENNIKLSE VVGSGKDGRI LKEDILNFLE KQTGAILPPS PKSEITPPPP QPRDRPFPTP 240
VSKPPVFLGK DRTEPVTGFQ KAMVKTMSAA LKIPHFGYCD EVDLTELVKL REELKPVALA 300
RGIKLSFMPF FLKAASLGLL QFPILNASVD ENCQSITYKA SHNIGIAMDT ERGLIVPNVK 360
NVQVRSVFEI AMELNRLQKL GSLGQLSTTD LTGGTFTLSN IGSIGGTYAK PVILPPEVAI 420
GALGAIKALP RFDQKGDVYK AQIMNVSWSA DHRVIDGATM SRFSNLWKSY LENPAFMLLD 480
LK 482 
Gene Ontology
 GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
 GO:0042645; C:mitochondrial nucleoid; IEA:Compara.
 GO:0048037; F:cofactor binding; IEA:InterPro.
 GO:0043754; F:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity; IEA:InterPro.
 GO:0046949; P:fatty-acyl-CoA biosynthetic process; IEA:InterPro. 
Interpro
 IPR003016; 2-oxoA_DH_lipoyl-BS.
 IPR001078; 2-oxoacid_DH_actylTfrase.
 IPR000089; Biotin_lipoyl.
 IPR023213; CAT-like_dom.
 IPR004167; E3-bd.
 IPR015761; Lip_Acyl_TA.
 IPR011053; Single_hybrid_motif. 
Pfam
 PF00198; 2-oxoacid_dh
 PF00364; Biotin_lipoyl
 PF02817; E3_binding 
SMART
  
PROSITE
 PS50968; BIOTINYL_LIPOYL
 PS00189; LIPOYL 
PRINTS