UniProt Accession

 NUPR1_RAT; O54842 

Genbank Protein ID

 AF014503 

Genbank Nucleotide ID

 AAB94673.1 

Protein Name

 Nuclear protein 1 

Protein Synonyms/Alias

 Candidate of metastasis 1; Protein p8 

Gene Name

 Nupr1 

Gene Synonyms/Alias

 Com1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
69	HERKLLTKFQNSERK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac) (By similarity). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3 (By similarity). NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to toxic agents, such as doxorubicin (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias (By similarity). 

Sequence Annotation

 MOTIF 64 80 Nuclear localization signal (Potential).  

Keyword

 Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 80 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 

Interpro

 IPR018792; Nuclear_phosphoprot_p8_DNA-bd. 

Pfam

 PF10195; Phospho_p8 

SMART

  

PROSITE

  

PRINTS