CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016296
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HEAT repeat-containing protein 5A 
Protein Synonyms/Alias
  
Gene Name
 HEATR5A 
Gene Synonyms/Alias
 C14orf125; KIAA1316 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
385DICQAIWKLKKVMDAubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
 REPEAT 846 883 HEAT 1.
 REPEAT 1079 1116 HEAT 2.
 MOD_RES 1110 1110 Phosphoserine.
 MOD_RES 1115 1115 Phosphothreonine.
 MOD_RES 1647 1647 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2040 AA 
Protein Sequence
MELAHSLLLN EEAYNQLGEV QKAEFIFEWL RYLEKLLLAT SRNDVREKQK TLVEQLLSLL 60
NSSPGPPTRK LLAKNLAILY SIGDTFSVHE AIDKCNDLIR SKDDSPSYLP TKLAAVVCLG 120
SLYKKLGRIL GNTFTDTVGN ILKAMKSAES QGRYEIMLSL QNILNGLGAA AAPCHRDVYK 180
AARSCLTDRS MAVRCAAAKN EAIFMWSTDL DSVATLCFKS FEGSNYDVRI SVSKLLGIIL 240
AKAVISKHPG TAASRQSIRR VSLEEVLELL GTGFLRGSSG FLRASGDMLK GTSSVSRDVR 300
VGVTQAYVVF VSTLGGAWLE KNFAAFFSHI LSLASPSHPK ATQTQIDAVC CRRCVSFILR 360
TTIGGLLGEK AQLAAVKDIC QAIWKLKKVM DAVMSDGNLE TRLGSTDVAA SQHMLVCALQ 420
ELGNLIHNLG TTAAPLLQDS STGLLDSILS VILHPSISVR LAAAWCLHCI AVALPSYLTP 480
LLDRCLERLT GHKSSPEAVT GFSFAVAALL GAVKHCPLGI PHGKGKIIMT LAEDLLCSAA 540
QNSRLSAQRT QAGWLLISAL MTLGPAVVSH HLARVLLLWK CVFPASPKDL ETEKSRGDSF 600
TWQVTLEGRA GALCAIKSFV SHCGDLLTEE VTQRLLPPLP CAVDLLTQLS SILKMYGSPL 660
KTPSVVYRQR LYELLILLPP ETYEGNLCAI LRELAADLTA PDIQVAASTF LLPPLCHQDD 720
LLILSPFLQE TDHRFIEEQL LLGNGVACGS LEYDPYSIYE KDVEGDSVPK PLPPALSVIS 780
SASKLFGVVC AHVGETQRLL ILEQLLDSIK HTKGARQQVV QLHVVSSVSS FLKYVAGSKG 840
CLGPEEMKRF ALTLVMGALE SPNPLLRCAA AESWARLAQV VDDGAFTAGL AQVSFDKLKS 900
ARDVVTRTGH SLALGSLHRY LGGISSSQHL NSCIGILYTL AQDSTSPDVQ TWALHSLSLI 960
IDSAGPLYYV HVEPTLSLII MLLLNVPPTH AEVHQSLGRC LNALITTLGP ELQGNSTSIS 1020
TLRTSCLLGC AVMQDNPDCL VQAQAISCLQ QLHMFAPRHV NLSSLVSCLC VNLCSPYLLL 1080
RRAVLACLRQ LVQREAAEVS EHAVMLAKDS REELTPDANI REVGLEGALL ILLDKETDER 1140
LCHDIKETLN YMLTSMAVEK LSLWLKLCKD VLAASADFTA VTCVDTMQEE EGDKGDDASV 1200
LTTRRDEKSH PFTNPRWATR VFAAECVCRI INQCENANSA HFDIALAQEM KKRDSRNDFL 1260
VLHLADLIRM AFMAATDHSD QLRLSGLEML LVVIRRFATV PEPEFPGHVI LEQYQANVGA 1320
ALRPAFTSET PPDVTAKACQ VCSAWIASGV VSDLNDLRRV HQLLVSSLTK IQAGKEALSH 1380
LYNESASTME ILAVLKAWAE VYIIAVQRHK NHRQPLKTTT CLEDGIRNGS CSSDGLLDLV 1440
YADLGTLSRL WLAALQDFAL LTLPSEFASQ LPAEGGAFYT AETSENAKLH YYNSWALILH 1500
ATALWLTSTG FVVADPDEGA SNLSRPVTPT SMCQGSSSGA TIKSPEDVYT DRFHLILGIS 1560
VEFLCSLRSD ATMESITACL HALQALLDVP WPRSKIGSDQ DLGIELLNVL HRVILTRESP 1620
SIQLASLEVV RQIICAAQEH VKEKRRSAEV DDGAAEKETL PEFGEGKDTG GLVPGKSLVF 1680
ATLELCVCIL VRQLPELNPK LTGSPGVKAT KPQILLEDGS RLVSAALVIL SELPAVCSPE 1740
GSISILPTIL YLTIGVLRET AVKLPGGQLS STVAASLQAL KGILSSPMAR AEKSRTAWTD 1800
LLRSALTTIL DCWDPVDETH QELDEVSLLT AITVFILSTS PEVTTIPCLQ KRCIDKFKAT 1860
LEIKDPVVQI KTYQLLHSIF QYPNPAVSYP YIYSLASCIM EKLQEIDKRK PENTAELEIF 1920
QEGIKVLETL VTVAEEHHRA QLVACLLPIL ISFLLDENSL GSATSIMRNL HDFALQNLMQ 1980
IGPQYSSVFK SLVASSPALK ARLEAAIKGN QESVKVKIPT SKYTKSPGKN SSIQLKTSFL 2040 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold. 
Pfam
  
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS