UniProt Accession

 ACBP_RAT; P11030; Q2V4X5; Q63160 

Genbank Protein ID

 M14201; M20268; Z11991; S51442; S51427; S51426; X96560; BC084717; Z21846 

Genbank Nucleotide ID

 AAA41078.1; AAA41079.1; AAA12824.1; AAA12824.1; AAA12824.1; CAA65396.1; AAH84717.1; CAA79894.1 

Protein Name

 Acyl-CoA-binding protein 

Protein Synonyms/Alias

 ACBP; Diazepam-binding inhibitor; DBI; Endozepine; EP; Triakontatetraneuropeptide; TTN; Octadecaneuropeptide; ODN 

Gene Name

 Dbi 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
8	MSQADFDKAAEEVKR	acetylation	[1]
14	DKAAEEVKRLKTQPT	acetylation	[1]
51	RPGLLDLKGKAKWDS	ubiquitination	[2]
77	AMKTYVEKVEELKKK	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. 

Sequence Annotation

 DOMAIN 2 87 ACB.
 REGION 29 33 Acyl-CoA binding (By similarity).
 BINDING 14 14 Acyl-CoA (By similarity).
 BINDING 51 51 Acyl-CoA (By similarity).
 BINDING 55 55 Acyl-CoA (By similarity).
 BINDING 74 74 Acyl-CoA (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 8 8 N6-acetyllysine (By similarity).
 MOD_RES 29 29 Phosphotyrosine (By similarity).
 MOD_RES 55 55 N6-acetyllysine; alternate (By
 MOD_RES 55 55 N6-malonyllysine; alternate (By
 MOD_RES 77 77 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Golgi apparatus; Lipid-binding; Phosphoprotein; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 87 AA 

Protein Sequence

Gene Ontology

 GO:0043292; C:contractile fiber; IDA:RGD.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0008021; C:synaptic vesicle; IDA:MGI.
 GO:0030156; F:benzodiazepine receptor binding; IDA:RGD.
 GO:0000062; F:fatty-acyl-CoA binding; IPI:RGD.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0006637; P:acyl-CoA metabolic process; TAS:RGD.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0031670; P:cellular response to nutrient; IEP:RGD.
 GO:0014009; P:glial cell proliferation; IDA:RGD.
 GO:0031999; P:negative regulation of fatty acid beta-oxidation; IDA:RGD.
 GO:0030157; P:pancreatic juice secretion; IEP:RGD.
 GO:0046889; P:positive regulation of lipid biosynthetic process; IDA:RGD.
 GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IMP:RGD.
 GO:0032228; P:regulation of synaptic transmission, GABAergic; IDA:MGI.
 GO:0006694; P:steroid biosynthetic process; TAS:RGD. 

Interpro

 IPR022408; Acyl-CoA-binding_prot_CS.
 IPR000582; Acyl-CoA-binding_protein.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx. 

Pfam

 PF00887; ACBP 

SMART

  

PROSITE

 PS00880; ACB_1
 PS51228; ACB_2 

PRINTS

 PR00689; ACOABINDINGP.