CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013329
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 
Protein Synonyms/Alias
 PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta 
Gene Name
 Ppp2r1b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
119EETVVRDKAVESLRQacetylation[1]
200VRRAAASKLGEFAKVacetylation[1]
200VRRAAASKLGEFAKVubiquitination[2]
267LRQAAEDKSWRVRYMacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (By similarity). 
Sequence Annotation
 REPEAT 20 58 HEAT 1.
 REPEAT 59 96 HEAT 2.
 REPEAT 97 135 HEAT 3.
 REPEAT 136 173 HEAT 4.
 REPEAT 174 212 HEAT 5.
 REPEAT 213 251 HEAT 6.
 REPEAT 252 290 HEAT 7.
 REPEAT 291 333 HEAT 8.
 REPEAT 334 372 HEAT 9.
 REPEAT 373 411 HEAT 10.
 REPEAT 412 450 HEAT 11.
 REPEAT 451 489 HEAT 12.
 REPEAT 490 528 HEAT 13.
 REPEAT 529 567 HEAT 14.
 REPEAT 568 601 HEAT 15.  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 601 AA 
Protein Sequence
MAGAAGPGTV PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR 60
TELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLESLAT VEETVVRDKA 120
VESLRQISQE HTPVALEAHF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ 180
HFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKTEIVPL FTNLASDEQD SVRLLAVEAC 240
VSIAQLLSQD DLEALVMPTL RQAAEDKSWR VRYMVADKFS ELQKAVGPKI ALSDLIPAFQ 300
SLLRDCEAEV RAAAAHKVRE LCENLPTEGR ETVIMNQILP YIKELVSDTN QHVKSALASV 360
IMGLSTVLGK ENTIEHLLPL FLAQLKDECP EVRLNIISNL DCVNEVIGIR QLSQSLLPAI 420
VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK 480
LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGKEITT KQMLPIVLKM 540
AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL 600
A 601 
Gene Ontology
 GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Compara. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000357; HEAT.
 IPR021133; HEAT_type_2. 
Pfam
 PF02985; HEAT 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS