| Tag | Content |
|---|
| CPLM ID | CPLM-023396 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog |
Protein Synonyms/Alias | Enhancer trap locus homolog 1; Etl-1 |
Gene Name | Etl1 |
Gene Synonyms/Alias | CG5899 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 475 | VMPKFFAKSIEDIKS | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity). |
Sequence Annotation | DOMAIN 301 471 Helicase ATP-binding.
DOMAIN 656 818 Helicase C-terminal.
NP_BIND 314 321 ATP (By similarity).
MOTIF 422 425 DEGH box.
MOD_RES 834 834 Phosphoserine.
MOD_RES 838 838 Phosphoserine.
MOD_RES 841 841 Phosphoserine. |
Keyword | Alternative splicing; ATP-binding; Chromatin regulator; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 844 AA |
Protein Sequence | MSDSTVAASA SASASSSAKS SLSDLRQFRI NKNASSVVAS PSRTERVPGK KRIQVMADSD 60
SDGNDSQTPK KTKLELTVKE KEERYMAAAK ISPHFDTMAI QESLSRTNWD VAASVRYLRE 120
NCKPKGHNGP LAKSKLKPRS NGISGGNFSD NDHSDDDDVK QSKDQVYDSD DSDSEMSTKM 180
TGQRKKVFQF MNEASLIELQ SVKTLSEKKA LAIIDVRPFS DWSDLRQKLE SIRMSGDLLN 240
YAQELINKQN TVAAILSKCN NMVSRLEKAI SNGAGIVEQP KLLSSGLQLA DYQIIGLNWL 300
TVMHKQEMNG ILADEMGLGK TIQVIAFLAY LKENGLSQAA HLIVVPSSTL DNWEAEISRW 360
CPELVVEKYH GSQDERRRMR GRFAKDGFTG FDVLLTTYHI VGSTPEERKM FRVCKLDYVI 420
FDEAHMLKNM TTQRYANLIT INARMRILLT GTPLQNNLLE LISLLCFVMP KFFAKSIEDI 480
KSLFAKKGKS DGDQDEVSQF QETQIQRAKR IMKPFVLRRL KKDVLKNLPK KLSLVEKVPM 540
SSQQKIYYHE LVDYYSNNKG EVCSSSERAG IAIMMEMRRI ANHPLLMRHY FTDANLRGFS 600
KRLANASSFK KTNEQYIFEE LAVMSDFQVY QMMNKHEFYD VKIPDNLICD SGKFLYLDTL 660
LPKLKAEGHR VLLFSQFTMM LDIVEEYLRI RKFGFCRLDG ATAVNVRQDL ITDFNGDDSI 720
FVFLLSTKAG GVGINLTAAD TCVIHDIDFN PYNDKQAEDR CHRMGQQRPV TIYRLISEST 780
IEEGILMAAE EKLKLEKDIT SNEKGEVHEQ RCVVKLLTTA LGLDKDQEEQ LNNSLNNSIA 840
SPAK 844 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |