| Tag | Content |
|---|
| CPLM ID | CPLM-011283 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | FACT complex subunit Ssrp1 |
Protein Synonyms/Alias | Chorion-factor 5; Facilitates chromatin transcription complex subunit Ssrp1; Recombination signal sequence recognition protein; Single-strand recognition protein; dSSRP1 |
Gene Name | Ssrp |
Gene Synonyms/Alias | CF5; SSRP1; CG4817 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 33 | TEQNIIFKNTKTGKV | acetylation | [1] | | 67 | WGLRVFTKGGVLHRF | acetylation | [1] | | 123 | GSVLSFDKESKTIFE | acetylation | [1] | | 364 | RGFIYIHKPPLHIRF | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U. The FACT complex is required for expression of Hox genes. |
Sequence Annotation | DNA_BIND 555 621 HMG box.
MOD_RES 443 443 Phosphoserine.
MOD_RES 628 628 Phosphoserine.
MOD_RES 664 664 Phosphoserine.
MOD_RES 668 668 Phosphoserine.
MOD_RES 669 669 Phosphothreonine.
MOD_RES 670 670 Phosphoserine.
MOD_RES 671 671 Phosphoserine. |
Keyword | 3D-structure; Chromosome; Complete proteome; Direct protein sequencing; DNA damage; DNA repair; DNA replication; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 723 AA |
Protein Sequence | MTDSLEYNDI NAEVRGVLCS GRLKMTEQNI IFKNTKTGKV EQISAEDIDL INSQKFVGTW 60
GLRVFTKGGV LHRFTGFRDS EHEKLGKFIK AAYSQEMVEK EMCVKGWNWG TARFMGSVLS 120
FDKESKTIFE VPLSHVSQCV TGKNEVTLEF HQNDDAPVGL LEMRFHIPAV ESAEEDPVDK 180
FHQNVMSKAS VISASGESIA IFREIQILTP RGRYDIKIFS TFFQLHGKTF DYKIPMDSVL 240
RLFMLPHKDS RQMFFVLSLD PPIKQGQTRY HYLVLLFAPD EETTIELPFS EAELRDKYEG 300
KLEKEISGPV YEVMGKVMKV LIGRKITGPG NFIGHSGTAA VGCSFKAAAG YLYPLERGFI 360
YIHKPPLHIR FEEISSVNFA RSGGSTRSFD FEVTLKNGTV HIFSSIEKEE YAKLFDYITQ 420
KKLHVSNMGK DKSGYKDVDF GDSDNENEPD AYLARLKAEA REKEEDDDDG DSDEESTDED 480
FKPNENESDV AEEYDSNVES DSDDDSDASG GGGDSDGAKK KKEKKSEKKE KKEKKHKEKE 540
RTKKPSKKKK DSGKPKRATT AFMLWLNDTR ESIKRENPGI KVTEIAKKGG EMWKELKDKS 600
KWEDAAAKDK QRYHDEMRNY KPEAGGDSDN EKGGKSSKKR KTEPSPSKKA NTSGSGFKSK 660
EYISDDDSTS SDDEKDNEPA KKKSKPPSDG DAKKKKAKSE SEPEESEEDS NASDEDEEDE 720
ASD 723 |
Gene Ontology | GO:0005694; C:chromosome; IEA:UniProtKB-SubCell. GO:0035101; C:FACT complex; IDA:FlyBase. GO:0031492; F:nucleosomal DNA binding; IDA:FlyBase. GO:0043621; F:protein self-association; IDA:FlyBase. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0006281; P:DNA repair; IEA:UniProtKB-KW. GO:0006260; P:DNA replication; IEA:UniProtKB-KW. GO:0022008; P:neurogenesis; IMP:FlyBase. GO:0001672; P:regulation of chromatin assembly or disassembly; IMP:FlyBase. GO:0051101; P:regulation of DNA binding; IMP:FlyBase. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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