CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004977
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Wnt-2 
Protein Synonyms/Alias
 INT-1-related protein; IRP 
Gene Name
 Wnt2 
Gene Synonyms/Alias
 Irp; Wnt-2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
142CSCDPKKKGSAKDSKacetylation[1]
146PKKKGSAKDSKGTFDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. 
Sequence Annotation
 LIPID 76 76 S-palmitoyl cysteine (By similarity).
 LIPID 212 212 O-palmitoyl serine; by PORCN (By
 CARBOHYD 295 295 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Developmental protein; Extracellular matrix; Glycoprotein; Lipoprotein; Palmitate; Reference proteome; Secreted; Signal; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 360 AA 
Protein Sequence
MNVPLGGIWL WLPLLLTWLT PEVSSSWWYM RATGGSSRVM CDNVPGLVSR QRQLCHRHPD 60
VMRAIGLGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV LLRSSRESAF VYAISSAGVV 120
FAITRACSQG ELKSCSCDPK KKGSAKDSKG TFDWGGCSDN IDYGIKFARA FVDAKERKGK 180
DARALMNLHN NRAGRKAVKR FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG 240
AIQVVMNQDG TGFTVANKRF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG 300
MDSCEVMCCG RGYDTSHVTR MTKCECKFHW CCAVRCQDCL EALDVHTCKA PKSADWATPT 360 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005615; C:extracellular space; IBA:RefGenome.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
 GO:0005109; F:frizzled binding; IBA:RefGenome.
 GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IMP:MGI.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:MGI.
 GO:0060317; P:cardiac epithelial to mesenchymal transition; IMP:MGI.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Compara.
 GO:0060716; P:labyrinthine layer blood vessel development; IMP:MGI.
 GO:0060492; P:lung induction; IGI:MGI.
 GO:0061180; P:mammary gland epithelium development; IEA:Compara.
 GO:0030182; P:neuron differentiation; IBA:RefGenome.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IMP:MGI.
 GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; IMP:MGI.
 GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Compara.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. 
Interpro
 IPR005817; Wnt.
 IPR009140; Wnt2.
 IPR018161; Wnt_CS. 
Pfam
 PF00110; wnt 
SMART
 SM00097; WNT1 
PROSITE
 PS00246; WNT1 
PRINTS
 PR01842; WNT2PROTEIN.
 PR01349; WNTPROTEIN.