CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006557
UniProt Accession
Genbank Protein ID
 L07296 
Genbank Nucleotide ID
Protein Name
 Vascular endothelial growth factor receptor 3 
Protein Synonyms/Alias
 VEGFR-3; Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4 
Gene Name
 Flt4 
Gene Synonyms/Alias
 Flt-4; Vegfr3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1064GLARDIYKDPDYVRKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr- 185', and of AKT1 at 'Ser-473'. 
Sequence Annotation
 DOMAIN 44 118 Ig-like C2-type 1.
 DOMAIN 151 213 Ig-like C2-type 2.
 DOMAIN 230 326 Ig-like C2-type 3.
 DOMAIN 331 415 Ig-like C2-type 4.
 DOMAIN 422 552 Ig-like C2-type 5.
 DOMAIN 555 671 Ig-like C2-type 6.
 DOMAIN 678 764 Ig-like C2-type 7.
 DOMAIN 845 1173 Protein kinase.
 NP_BIND 851 859 ATP (By similarity).
 ACT_SITE 1037 1037 Proton acceptor (By similarity).
 BINDING 879 879 ATP (By similarity).
 MOD_RES 830 830 Phosphotyrosine; by SRC (By similarity).
 MOD_RES 833 833 Phosphotyrosine; by SRC (By similarity).
 MOD_RES 1063 1063 Phosphotyrosine; by autocatalysis and SRC
 MOD_RES 1068 1068 Phosphotyrosine; by autocatalysis (By
 MOD_RES 1230 1230 Phosphotyrosine; by autocatalysis (By
 MOD_RES 1231 1231 Phosphotyrosine; by autocatalysis (By
 MOD_RES 1265 1265 Phosphotyrosine; by autocatalysis (By
 MOD_RES 1333 1333 Phosphotyrosine; by autocatalysis and SRC
 MOD_RES 1337 1337 Phosphotyrosine; by autocatalysis and SRC
 MOD_RES 1363 1363 Phosphotyrosine; by autocatalysis (By
 CARBOHYD 33 33 N-linked (GlcNAc...) (Potential).
 CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
 CARBOHYD 166 166 N-linked (GlcNAc...) (Potential).
 CARBOHYD 251 251 N-linked (GlcNAc...) (Potential).
 CARBOHYD 299 299 N-linked (GlcNAc...) (Potential).
 CARBOHYD 411 411 N-linked (GlcNAc...) (Potential).
 CARBOHYD 515 515 N-linked (GlcNAc...) (Potential).
 CARBOHYD 527 527 N-linked (GlcNAc...) (Potential).
 CARBOHYD 582 582 N-linked (GlcNAc...).
 CARBOHYD 594 594 N-linked (GlcNAc...) (Potential).
 CARBOHYD 683 683 N-linked (GlcNAc...) (Potential).
 CARBOHYD 690 690 N-linked (GlcNAc...) (Potential).
 CARBOHYD 758 758 N-linked (GlcNAc...) (Potential).
 DISULFID 51 111 By similarity.
 DISULFID 158 206 By similarity.
 DISULFID 252 310 By similarity.
 DISULFID 445 534 By similarity.
 DISULFID 578 653 By similarity.
 DISULFID 699 751 By similarity.  
Keyword
 Angiogenesis; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1363 AA 
Protein Sequence
MQPGAALNLR LWLCLGLLQG LANGYSMTPP TLNITEDSYV IDTGDSLSIS CRGQHPLEWT 60
WPGAQEVLTT GGKDSEDTRV VHDCEGTEAR PYCKVLLLAQ THANNTGSYH CYYKYIKARI 120
EGTTAASTYV FVRDFKHPFI NKPDTLLVNR KDSMWVPCLV SIPGLNITLR SQSSALHPDG 180
QEVLWDDRRG MRVPTQLLRD ALYLQCETTW GDQNFLSNLF VVHITGNELY DIQLYPKKSM 240
ELLVGEKLVL NCTVWAEFDS GVTFDWDYPG KQAERAKWVP ERRSQQTHTE LSSILTIHNV 300
SQNDLGPYVC EANNGIQRFR ESTEVIVHEK PFISVEWLKG PVLEATAGDE LVKLPVKLAA 360
YPPPEFQWYK DRKAVTGRHN PHALVLKEVT EASAGVYTLA LWNSAAGLRQ NISLELVVNV 420
PPHIHEKEAS SPSIYSRHSR QTLTCTAYGV PQPLSVQWHW RPWTPCKTFA QRSLRRRQQR 480
DGMPQCRDWK EVTTQDAVNP IESLDSWTEF VEGKNKTVSK LVIQDANVSA MYKCVVVNKV 540
GQDERLIYFY VTTIPDGFSI ESEPSEDPLE GQSVRLSCRA DNYTYEHLRW YRLNLSTLHD 600
AQGNPLLLDC KNVHLFATPL EANLEEAEPG ARHATLSLNI PRVAPEDEGD YVCEVQDRRS 660
QDKHCHKKYL SVQALEAPRL TQNLTDLLVN VSDSLEMRCP VAGAHVPSIV WYKDERLLEK 720
ESGIDLADSN QRLSIQRVRE EDAGRYLCSV CNAKGCVNSS ASVAVEGSED KGSMEIVILI 780
GTGVIAVFFW VLLLLIFCNM KRPAHADIKT GYLSIIMDPG EVPLEEQCEY LSYDASQWEF 840
PRERLHLGRV LGHGAFGKVV EASAFGINKG SSCDTVAVKM LKEGATASEH RALMSELKIL 900
IHIGNHLNVV NLLGACTKPN GPLMVIVEFC KYGNLSNFLR VKRDTFNPYA EKSPEQRRRF 960
RAMVEGAKAD RRRPGSSDRA LFTRFLMGKG SARRAPLVQE AEDLWLSPLT MEDLVCYSFQ 1020
VARGMEFLAS RKCIHRDLAA RNILLSESDI VKICDFGLAR DIYKDPDYVR KGSARLPLKW 1080
MAPESIFDKV YTTQSDVWSF GVLLWEIFSL GASPYPGVQI NEEFCQRLKD GTRMRAPELA 1140
TPAIRHIMQS CWSGDPKARP AFSDLVEILG DLLQGGGWQE EEEERMALHS SQSSEEDGFM 1200
QASTTALHIT EADADDSPPS MHCHSLAARY YNCVSFPGRL ARGTKTPGSS RMKTFEELPM 1260
TPTTYKASMD NQTDSGMVLA SEEFEELESR HRPEGSFSCK GPGQHMDIPR GHPDPQGRRR 1320
RPTQGAQGGK VFYNNEYGEV SQPCTEGDCC PSAGSTFFAD SSY 1363 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IGI:MGI.
 GO:0001946; P:lymphangiogenesis; IMP:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IGI:MGI.
 GO:0010595; P:positive regulation of endothelial cell migration; IEA:Compara.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Compara.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0046330; P:positive regulation of JNK cascade; IEA:Compara.
 GO:0090037; P:positive regulation of protein kinase C signaling cascade; IEA:Compara.
 GO:0001934; P:positive regulation of protein phosphorylation; IEA:Compara.
 GO:0010575; P:positive regulation vascular endothelial growth factor production; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0060312; P:regulation of blood vessel remodeling; IMP:UniProtKB.
 GO:0002040; P:sprouting angiogenesis; IMP:UniProtKB.
 GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:Compara. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR001824; Tyr_kinase_rcpt_3_CS.
 IPR009137; Tyr_kinase_VEGFR3_rcpt_N.
 IPR009134; Tyr_kinase_VEGFR_rcpt_N. 
Pfam
 PF07679; I-set
 PF07714; Pkinase_Tyr 
SMART
 SM00409; IG
 SM00408; IGc2
 SM00219; TyrKc 
PROSITE
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00240; RECEPTOR_TYR_KIN_III 
PRINTS
 PR01832; VEGFRECEPTOR.
 PR01835; VEGFRECEPTR3.