CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026679
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylate kinase 
Protein Synonyms/Alias
 AK; ATP-AMP transphosphorylase; ATP:AMP phosphotransferase; Adenylate monophosphate kinase 
Gene Name
 adk 
Gene Synonyms/Alias
 RPA3229 
Created Date
 July 27, 2013 
Organism
 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 
NCBI Taxa ID
 258594 
Lysine Modification
Position
Peptide
Type
References
231ATKGKAAKSAAKAPKacetylation[1]
Reference
 [1] System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
 Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.
 J Biol Chem. 2012 May 4;287(19):15590-601. [PMID: 22416131] 
Functional Description
 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). 
Sequence Annotation
 NP_BIND 10 15 ATP (By similarity).
 NP_BIND 85 88 AMP (By similarity).
 REGION 30 59 NMPbind (By similarity).
 REGION 126 142 LID (By similarity).
 BINDING 31 31 AMP (By similarity).
 BINDING 36 36 AMP (By similarity).
 BINDING 92 92 AMP (By similarity).
 BINDING 127 127 ATP (By similarity).
 BINDING 139 139 AMP (By similarity).
 BINDING 150 150 AMP (By similarity).
 BINDING 178 178 ATP; via carbonyl oxygen (By similarity).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide biosynthesis; Nucleotide-binding; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 371 AA 
Protein Sequence
MRLILLGPPG AGKGTQAGRL VEQHGIVQLS TGDMLRAAVA AGTPIGLKAK DIMAAGGLVP 60
DEVVIGIISD RIDQDDAAQG FILDGFPRTV PQAEALDRLL KDKGFDLDAV VELKVNEGAL 120
LDRVETRVAE MRARGEEPRA DDNAEALAKR LSAYRAQTEP LVDYYSEKRK LLTVDGMMTI 180
DEVTREIGRV LDAVRAADAK KGAKAKGTKA SRAKRTVKTA KKAATKGKAA KSAAKAPKKA 240
AAKPAAKSGA KSGSAKKSSA KQTVGKKSSG KTAVSKKVAG KPAASKAGKA AVGKTAKAGL 300
KKAAKAVAKA GKKAAKAAVK AAKGAAKPTA GKKAAGKKAT KKAAATSKAK AVAKAPARGS 360
KKAKKATKKR A 371 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004017; F:adenylate kinase activity; IEA:HAMAP.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway. 
Interpro
 IPR006259; Adenyl_kin_sub.
 IPR000850; Adenylate_kin.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00406; ADK 
SMART
  
PROSITE
 PS00113; ADENYLATE_KINASE 
PRINTS
 PR00094; ADENYLTKNASE.