CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029940
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 T-complex protein 1 subunit zeta-2 
Protein Synonyms/Alias
  
Gene Name
 Cct6b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
338LSVTLLVKGPNKHTLacetylation[1, 2, 3]
338LSVTLLVKGPNKHTLubiquitination[4]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 492 AA 
Protein Sequence
MLISENLLVS GAGDIKLTKD GNVLLHEMQI QHPTASIIAK VAAAQDHVTG DGTTSNVLII 60
GELLKQADLY ISEGLHPRII TEGFDVAKTK ALEVLDEIKV QKEMKREILL DVARTSLQTK 120
VHAELADILT EAVVDSVLAI RRPGVPIDLF MVEIVEMRHK SETDTQLIRG LVLDHGARHP 180
RMRKQVRDAY ILTCNVSLEY EKTEVSSGFF YKTVEEKEKL VKAERKFIED RVQKIIDLKQ 240
KVCAESNKGF VVINQKGIDP VSLEMLAKHN IVALRRAKRR NLERLTLACG GLAVNSFEGL 300
SEECLGHAGL VFEYALGEEK FTFIEDCVNP LSVTLLVKGP NKHTLIQIKD ALRDGLRAVK 360
NAIEDGCVVP GAGAVEVAIA EALVNYKHRV QGRVRLGIQA FADALLIIPK VLAQNSGYDL 420
QETLIKIQTK HAESKELLGI DLNTGEPMAA AEAGIWDNYC VKKHLLHSCT VIATNILLVD 480
EIMRAGMSSL RD 492 
Gene Ontology
 GO:0005832; C:chaperonin-containing T-complex; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR012722; Chap_CCT_zeta.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00751; TCP1_2
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.