CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007308
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Securin 
Protein Synonyms/Alias
  
Gene Name
 PDS1 
Gene Synonyms/Alias
 YDR113C; YD9727.08C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
155SNSRKLQKYGSVLGYacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Regulatory protein, which plays a central role in chromosome stability. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESP1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESP1. 
Sequence Annotation
 MOTIF 85 88 D-box.
 MOD_RES 185 185 Phosphoserine.
 MOD_RES 186 186 Phosphoserine.
 MOD_RES 212 212 Phosphoserine.
 MOD_RES 213 213 Phosphoserine.
 MOD_RES 277 277 Phosphoserine.
 MOD_RES 292 292 Phosphoserine; by CDC28 (Probable).  
Keyword
 Cell cycle; Cell division; Chromosome partition; Complete proteome; Cytoplasm; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 373 AA 
Protein Sequence
MMPANEDKEN NIVYTGNESS GINFPQTPAH LLKRSHSNIL KPPVRLDQLK RDANSNNGNT 60
LKYIQGGKEV SPTKRLHTHA QQQGRLPLAA KDNNRSKSFI FPETSNQSKD ADLPQLQNTL 120
SIRKNDQLRK LSQISRSRSR ANHNDLLSNS RKLQKYGSVL GYNALPKMKS LVLKDLADSG 180
KNEESSDDDE GNEDSESKLG KKLQSALLKQ DSSDGENELN GGLGLFNEQG GLQQLIKNST 240
KNEQKTKNDK SDKTDDYDIE IAPQRQEPLP YVPEGYSPFQ QDDIEKLKTF NSPYKLDLED 300
EDDTPDKVDL LPLEQIDEEG EKDETECITR NQEEGAALPL LSKNFKEVAA VPTMELVYSE 360
EGLDPEELED LVT 373 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005819; C:spindle; IDA:SGD.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007127; P:meiosis I; IMP:SGD.
 GO:0000070; P:mitotic sister chromatid segregation; IPI:SGD.
 GO:0008104; P:protein localization; IMP:SGD.
 GO:0000725; P:recombinational repair; IMP:SGD. 
Interpro
 IPR006940; Securin_separation_inhibitor. 
Pfam
 PF04856; Securin 
SMART
  
PROSITE
  
PRINTS