| Tag | Content |
|---|
| CPLM ID | CPLM-011991 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lymphocyte cytosolic protein 2 |
Protein Synonyms/Alias | SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein; SLP76 |
Gene Name | LCP2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 438 | EAEAALRKINQDGTF | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Involved in T-cell antigen receptor mediated signaling. |
Sequence Annotation | DOMAIN 15 81 SAM.
DOMAIN 422 530 SH2.
MOD_RES 23 23 Phosphotyrosine (By similarity).
MOD_RES 207 207 Phosphoserine. |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; SH2 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 533 AA |
Protein Sequence | MALRNVPFRS EVLGWDPDSL ADYFKKLNYK DCEKAVKKYH IDGARFLNLT ENDIQKFPKL 60
RVPILSKLSQ EINKNEERRS IFTRKPQVPR FPEETESHEE DNGGWSSFEE DDYESPNDDQ 120
DGEDDGDYES PNEEEEAPVE DDADYEPPPS NDEEALQNSI LPAKPFPNSN SMYIDRPPSG 180
KTPQQPPVPP QRPMAALPPP PAGRNHSPLP PPQTNHEEPS RSRNHKTAKL PAPSIDRSTK 240
PPLDRSLAPF DREPFTLGKK PPFSDKPSIP AGRSLGEHLP KIQKPPLPPT TERHERSSPL 300
PGKKPPVPKH GWGPDRREND EDDVHQRPLP QPALLPMSSN TFPSRSTKPS PMNPLPSSHM 360
PGAFSESNSS FPQSASLPPY FSQGPSNRPP IRAEGRNFPL PLPNKPRPPS PAEEENSLNE 420
EWYVSYITRP EAEAALRKIN QDGTFLVRDS SKKTTTNPYV LMVLYKDKVY NIQIRYQKES 480
QVYLLGTGLR GKEDFLSVSD IIDYFRKMPL LLIDGKNRGS RYQCTLTHAA GYP 533 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0050663; P:cytokine secretion; IEA:Compara. GO:0045087; P:innate immune response; TAS:Reactome. GO:0045576; P:mast cell activation; IEA:Compara. GO:0030168; P:platelet activation; TAS:Reactome. GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome. GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |