CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034746
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Med12 
Protein Synonyms/Alias
  
Gene Name
 Med12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
15SYEHRPLKRLRLGPPacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2187 AA 
Protein Sequence
MAAFGILSYE HRPLKRLRLG PPDVYPQDPK QKEDELTALN VKQGFNNQPA VSGDEHGSAK 60
NVNFNPAKIS SNFSSIIAEK LRCNTLSDTG RRKSLMNQKD NFWLVTARSQ SAINTWFTDL 120
AGTKPLTHLA KKVPIFSKKE EVFGYLAKYT VPVMRAAWLI KMTCAYYAAM SETKVKKKNT 180
ADPFTEWTQI ITKYLWEQLQ KMAEYYRPGP AGSGVCGSAI GPLPHDVEMA IRQWDYNEKL 240
ALFMFQDGML DRHEFLTWVL ECFEKIRPGE DELLKLLLPL LLRYSGEFVQ SAYLSRRLAY 300
FCTRRLALQL DGVNSHSSHV ISAQSTSSLP TTPAPQPPTS NTPSTPFSDL LMCPQHRPLV 360
FGLSCILQTI LLCCPSALVW HYSLTDSRIK TGSPLDHLPI APSNLPMPEG NSAFTQQVRA 420
KLREIEQQIK ERGQAVEVRW SFDKCQEATA GFTIGRVLHT LEVLDSHSFE RSDFSNSLDS 480
LCNRIFGLGP SKDGHEISSD DDAVVSLLCE WAVSCKRSGR HRAMVVAKLL EKRQAEIEAE 540
RCGESEAADE KGSVASGSLS APSAPIFQDV LLQFLDTQAP MLTDPRSESE RVEFFNLVLL 600
FCELIRHDVF SHNMYTCTLI SRGDLAFGTP GPRPPSPFDD PADDPERKEA EGSSSSKLED 660
PGLSESMDID PSSSVLFEDM EKPDFSLFSP TMPCEGKGSP SPEKPDVEKD VKPPPKEKIE 720
GTLGILYDQP RHVQYATHFP IPQEESCSHE CNQRLVVLFG VGKQRDDARH AIKKITKDIL 780
KVLNRKGTAE TDQLAPIVPL NPGDLTFLGG EDGQKRRRNR PEAFPTAEDI FAKFQHLSHY 840
DQHQVTAQVS RNVLEQITSF ALGMSYHLPL VQHVQFVFDL MEYSLSISGL IDFAIQLLNE 900
LSVVEAELLL KSSDLVGSYT TSLCLCIVAV LRHYHACLIL NQDQMAQVFE GLCGVVKHGM 960
NRSDGSSAER CILAYLYDLY TSCSHLKSKF GELFSDFCSK VKNTIYCNVE PSESNMRWAP 1020
EFMIDTLENP AAHTFTYTGL GKSLSENPAN RYSFVCNALM HVCVGHHDPD RVNDIAILCA 1080
ELTGYCKSLS AEWLGVLKAL CCSSNNGTCG FNDLLCNVDV SDLSFHDSLA TFVAILIARQ 1140
CLLLEDLIRC AAIPSLLNAA CSEQDSEPGA RLTCRILLHL FKTPQLNPCQ SDGNKPTVGI 1200
RSSCDRHLLA ASQNRIVDGA VFAVLKAVFV LGDAELKGSG FTVPGGTEEL PEEEGGGGSS 1260
GRRQGGRNIS VETASLDVYA KYVLRSICQQ EWVGERCLKS LCEDSNDLQD PVLSSAQAQR 1320
LMQLICYPHR LLDSEDGENP QRQRIKRILK NLDQWTMRQS SLELQLMIKQ TPNTEMNSLL 1380
ENIAKATIEV FQQSAETGSS SGSTASNMPS SSKAKPVLSS LERSGVWLVA PLIAKLPTSV 1440
QGHVLKAAGE ELEKGQHLGS SSRKERDRQK QKSMSLLSQQ PFLSLVLTCL KGQDEQREGL 1500
LASLHSQVHQ IVINWRENQY LDDCKPKQLM HEALKLRLNL VGGMFDTVQR STQQTTEWAQ 1560
LLLEIIISGT VDMQSNNELF TTVLDMLSVL INGTLAADMS SISQGSMEEN KRAYMNLVKK 1620
LQKDLGERQS DSLEKVHQLL PLPKQNRDVI TCEPQGSLID TKGNKIAGFD SIFKKEGLQV 1680
STKQKISPWE LFEGLKPSTA PLSWAWFGTV RVDRRVARGE EQQRLLLYHT HLRPRPRAYY 1740
LEPLPLPPED EEPPAPALLE PEKKAPEPPK TDKPGTAPPS TEERKKKSTK GKKRSQPATK 1800
SEDYGMGPGR SGPYGVTVPP DLLHHANPGS ISHLSYRQSS MGLYTQNQPL PAGGPRVDPY 1860
RPVRLPMQKL PTRPTYPGVL PTTMTTVMGL EPSSYKTSVY RQQQPTVPQG QRLRQQLQQS 1920
QGMLGQSSVH QMTPSSSYGL QSSQGYTSYV SHVGLQQHTG PAGTMVPPSY SSQPYQSTHP 1980
STNPTLVDPT RHLQQRPSGY VHQQAPTYGH GLTSTQRFSH QTLQQTPMMG TMTPLSAQGV 2040
QAGVRSTSIL PEQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQYHIRQQ QQQQQILRQQ 2100
QQQQQQQQQQ QQQQQQQQQQ QPQQQQPHQQ QQQAAPPQPQ PQSQPQFQRQ GLQQTQQQQQ 2160
TAALVRQLQQ QLSNTQPQPS TNIFGRY 2187 
Gene Ontology
 GO:0016592; C:mediator complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0004872; F:receptor activity; IEA:Compara.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0030521; P:androgen receptor signaling pathway; IEA:Compara.
 GO:0090245; P:axis elongation involved in somitogenesis; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IEA:Compara.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0019827; P:stem cell maintenance; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:Compara.
 GO:0060071; P:Wnt receptor signaling pathway, planar cell polarity pathway; IEA:Compara. 
Interpro
 IPR019035; Mediator_Med12.
 IPR021989; Mediator_Med12_catenin-bd.
 IPR021990; Mediator_Med12_LCEWAV. 
Pfam
 PF09497; Med12
 PF12145; Med12-LCEWAV
 PF12144; Med12-PQL 
SMART
  
PROSITE
  
PRINTS