CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014661
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2-hydroxyacylsphingosine 1-beta-galactosyltransferase 
Protein Synonyms/Alias
 Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase 
Gene Name
 Ugt8 
Gene Synonyms/Alias
 Cgt; Ugt4; Ugt8a 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
89SDAFLQSKMRNIFSGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. 
Sequence Annotation
 CARBOHYD 78 78 N-linked (GlcNAc...) (Potential).
 CARBOHYD 333 333 N-linked (GlcNAc...) (Potential).
 CARBOHYD 442 442 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Glycosyltransferase; Lipid metabolism; Membrane; Reference proteome; Signal; Sphingolipid metabolism; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 541 AA 
Protein Sequence
MKSYTPYFML LWSAVGIARA AKIIIVPPIM FESHLYIFKT LASALHERGH HTVLLLSEGR 60
DIAPSNHYSL QRYPGIFNST TSDAFLQSKM RNIFSGRLTA VELVDILDHY TKNCDMMVGN 120
QALIQGLKKE KFDLLLVDPN DMCGFVIAHL LGVKYAVFST GLWYPAEVGA PAPLAYVPEF 180
NSLLTDRMNF LERMKNTGVY LISRIGVSFL VLPKYERIMQ KYNLLPAKSM YDLVHGSSLW 240
MLCTDVALEF PRPTLPNVVY VGGILTKPAS PLPEDLQRWV SGAQEHGFVL VSFGAGVKYL 300
SEDIANKLAG ALGRLPQKVI WRFSGTKPKN LGNNTKLIEW LPQNDLLGHS NIRAFLSHGG 360
LNSIFETMYH GVPVVGIPLF GDHYDTMTRV QAKGMGILLE WNTVTEGELY DALVKVINNP 420
SYRQRAQKLS EIHKDQPGHP VNRTTYWIDY ILRHDGARHL RSAVHQISFC QYFLLDIAFV 480
LLLGAVLLYF ILSYVTKFIY RKIKSLWSKN EHSTVNGHYQ NGIRNGKYKG NGRVKHEKKV 540
R 541 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0003851; F:2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity; IEA:EC.
 GO:0008120; F:ceramide glucosyltransferase activity; TAS:MGI.
 GO:0008489; F:UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity; IEA:Compara.
 GO:0008088; P:axon cargo transport; IMP:BHF-UCL.
 GO:0007010; P:cytoskeleton organization; IMP:BHF-UCL.
 GO:0006682; P:galactosylceramide biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009247; P:glycolipid biosynthetic process; TAS:MGI.
 GO:0048812; P:neuron projection morphogenesis; IMP:BHF-UCL.
 GO:0030913; P:paranodal junction assembly; IMP:BHF-UCL.
 GO:0002175; P:protein localization to paranode region of axon; IMP:BHF-UCL. 
Interpro
 IPR002213; UDP_glucos_trans. 
Pfam
 PF00201; UDPGT 
SMART
  
PROSITE
 PS00375; UDPGT 
PRINTS