CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033028
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 EH domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 EHD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84KIRVVLNKADQIETQubiquitination[1, 2]
144AEEQDLFKDIQSLPRubiquitination[1]
157PRNAALRKLNDLIKRubiquitination[2]
188EMPNVFGKESKKKELacetylation[3]
192VFGKESKKKELVNNLubiquitination[2, 4]
193FGKESKKKELVNNLGubiquitination[4]
205NLGEIYQKIEREHQIubiquitination[2, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 306 AA 
Protein Sequence
MCAQLPNPVL DSISIIDTPG ILSGEKQRIS RGYDFAAVLE WFAERVDRII LLFDAHKLDI 60
SDEFSEVIKA LKNHEDKIRV VLNKADQIET QQLMRVYGAL MWSLGKIINT PEVVRVYIGS 120
FWSHPLLIPD NRKLFEAEEQ DLFKDIQSLP RNAALRKLND LIKRARLAKV HAYIISSLKK 180
EMPNVFGKES KKKELVNNLG EIYQKIEREH QISPGDFPSL RKMQELLQTQ DFSKFQALKP 240
KLLDTVDDML ANDIARLMVM VRQEESLMPS QVVKGGAFDG TMNGPFGHGY GEGAGEGIDD 300
VEWVVG 306 
Gene Ontology
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0030139; C:endocytic vesicle; IEA:Compara.
 GO:0005811; C:lipid particle; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0031095; C:platelet dense tubular network membrane; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0006897; P:endocytosis; IEA:Compara.
 GO:0016197; P:endosomal transport; IEA:Compara.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0034383; P:low-density lipoprotein particle clearance; IEA:Compara.
 GO:0010886; P:positive regulation of cholesterol storage; IEA:Compara. 
Interpro
 IPR001401; Dynamin_GTPase.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00350; Dynamin_N 
SMART
  
PROSITE
  
PRINTS