| Tag | Content |
|---|
| CPLM ID | CPLM-015728 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mediator of RNA polymerase II transcription subunit 13 |
Protein Synonyms/Alias | Mediator complex subunit 13; Mediator complex subunit Skuld; Protein blind spot; Protein poils aux pattes; dTRAP240 |
Gene Name | skd |
Gene Synonyms/Alias | bli; Med13; pap; Trap240; CG9936 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1815 | SRGGSGSKDASSYNT | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for leg and eye development and macrochaete specification or differentiation. Negatively regulates sex comb development. Required for activated transcription of the MtnB and MtnD genes. |
Sequence Annotation | MOD_RES 571 571 Phosphothreonine.
MOD_RES 575 575 Phosphothreonine.
MOD_RES 2472 2472 Phosphoserine.
MOD_RES 2475 2475 Phosphoserine. |
Keyword | Activator; Complete proteome; Developmental protein; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2618 AA |
Protein Sequence | MTHQNHQTNG ASLEDCHTNF YALTDLCGIK WRKFVNGERP NASSDPLADP ILRSYSRCIQ 60
ADMLCVWRRV QSTKTDHADP NALTFEMTTS TKVHPPLSLA AAKELWIFWY GEEPDLSELV 120
DAELLRVAAN QALWNGTWKG ALTYECRSLL FKALHNLMER FVLTKDIVRF GKWFVQPCTS 180
SDRLFGRSSQ HLSFSFTFFV HGDTVCASID LREHPAVRPL TKEHLTEAAA AFAAASSPPG 240
SNGSAASAGG AVPNPGQDPN GASMDGLDGG EGAAKAAPPP HARKVMLAPF GIAGILTGNS 300
YKASDPIAEK ILEDWASFFP LCNKDNTDVP PVVEVVSGGH KMYHPTNYVL VTDLDDMEHM 360
EFVEMQKMQS SVAGAAAESA VLASLSCPPG AASAPSSMGA APSATAVPLG PASLNAPALA 420
GAGVGATASS AAKEISRKAA PQAVSALERL AFQPYYDQRP TSGFTFNTNN THIPASAAVE 480
MPERTWQDCV MNTLHVDAAA AAAAVASSTP ASGTGSLSAD GDENEQNKPP QDSKQLVQQQ 540
IQQQQQRQKL WNFVDPMQKA PCICTKHLGN TPHGTPHGGA STYSRNSLGG DSSMPVASVE 600
SPATPAPSPH PNSAHSQPTS VPPAEQLLNM SPHAPTSVSN LQQPPTPIDH LLDKNTPAPT 660
PTDQHDSKSI TASPYVHQTP SVEPPSYTDH AAGGGPAGGQ GLGTGPGSVP AQQPATPTAA 720
TSAGGAGSGG PSNAIGANAV GTISVKKLEM QQQTPSAAMA IKQEPGAQGR GVGGVTSTTE 780
ALNNFKRLYN PPKLTLKDPD SFYDEEWLKE VIYDFQYQEY WDYSTVKRPK MEKQRRPRYA 840
KNLYEGQNHV KPVMPSPGSV YGSQLLSLDE SASQAGGRGG GGQAAGSSGG GLVGIANSTA 900
SGSDVEADGS SFFQGLNIKT EPGLHSPSCK ETSKSSGGNS SGGGSGSGGN LFTAEGLNPS 960
LNDLEQLFET SSNDECSSVQ IHTPPDSNNP SNGGCSAVTN TIEDLKRSTA VASAAVAAAA 1020
AAAASGAGNI QAEDLTKMFP TPPSHEQQHP NSSPCQTDVV MTDLSVDTTT TIITSSITTT 1080
CNTTITSSIN TTTTACSNPS NSIMLAAAQA PVTVVAIQTV SKMVKQEYNL ELGSPMEEPI 1140
NDWDYVYRPP QQEKFVGSTR YAPLTNLPSQ TQPPLTLPTG CFYQPTWSSH KSRAATLAKA 1200
AAAQQQQHQK HQALQQRIQL HQQKLQQLQL QNQQQQQAAA AAAAAASGGV GHQKHQHQHL 1260
HDLLSAAPRT PLTPSTVPQP LSSGGSQYLL NQLNCPQAPP GASMQQLMHR AGMSPISPGP 1320
GMGPYAARSS PMSRATPTHP PPPYPYDLAV ASPATSTSSY LNRPLHSQEH PHMHGLGGGA 1380
TGVVGHGTGG GGHMGMVAYT GDAGIVSGGT AMAAGSSSLL QELPEVNSVL VNILLYDTAL 1440
NVFRDHNFDS SSVCVCNADT QKIGNIRGAD SGVYVPLPGV SFNPFPSGAG GALAGQRMLN 1500
GPSSAGFGGM RMISAFGGSP ASASMPGAGS GHGHGPNGGS NSSSCTPPSS NPHITGYVDD 1560
DPVECTCGFS AVVNRRLSHR AGLFYEDEVE ITGIADDPGR NKQPTLLSII QSLSRKNQNK 1620
QGPGETSSAL DKIGAGGLPN GQLEQLGHAV FDLLLDQCSI IQTSSSSVHR ALQSHRRRMS 1680
RQRRIFGNNG APTASLASIA NVLEFMDAHD VISLALEQSR LAFENQRMDN MMDFHGNGSS 1740
SSHQQQQLTA FHAPPPALRH KLAGIGAGRL TVHKWPYLPV GFTRSNKEIV RTMNAIQPML 1800
QNAFHCKSRG GSGSKDASSY NTVSGPLTWR QFHRLAGRAS GQCEPQPIPS VVVGYEKDWI 1860
SVAPHSIHYW DKFLLEPYSY ARDVVYVVVC PDNEHVVNCT RSYFRELSST YEMCKLGKHT 1920
PIRGWDGFLQ VGAARNNVPA DRETTPLDDW LRTLEHAALA EQIRRYAVAF IHQLAPYLSR 1980
VPNDKTLLNP PDGSGNSHSK GGSSCSSNSS SVSGLPGGDL PTDNIKLEPG TEPQVQPMET 2040
NEIKQEPGVG KGGTAAGETK PTLILGDPLG MGETLEDINP SAIVLYVVNP FTFASDSCEL 2100
ERLALIALLR CYAELLKAVP DSVRSQMNIQ IISLESVMEL GPCGNRKRFS DEIRCLALNI 2160
FSQCRRHLVH AQSVKSLTGF GTAANMEAFL KTKDEPNRRA YKMYTAPFVL APMHERNDKT 2220
DFSRSAGSMH GQNEHRYSVM YCNYCLSEDQ AWLLATATDE RGEMLEKICI NIDVPNRARR 2280
RKAPARYVAL KKLMDFIMGI ISQTSQMWRL VIGRIGRIGH SELKSWSFLL SKQQLQKASK 2340
QFKDMCKQCT LMYPPTILSA CLVTLEPDAK LRVMPDQFTP DERFSQISMQ NPLATPQDVT 2400
CTHILVFPTS AVCAPFTRQF QNEPQVDDDF LTFEEEGNED FSDADIGDLF WDTHMDRVSN 2460
HGSPGRMDDN RSWQSAGGNN FKCTPPQEVE EVGSLNQQPI SVGYMVSTAP TGRMPAWFWS 2520
ACPHLEDVCP VFLKTALHLH VPSIQSADDI LNSTNAHQSG NDHPLDSNLT ADVLRFVLEG 2580
YNALSWLALD SNTHDRLSCL PINVQTLMDL YYLTAAIA 2618 |
Gene Ontology | GO:0016592; C:mediator complex; IDA:UniProtKB. GO:0001104; F:RNA polymerase II transcription cofactor activity; IDA:UniProtKB. GO:0045165; P:cell fate commitment; IGI:FlyBase. GO:0022416; P:chaeta development; IMP:FlyBase. GO:0048749; P:compound eye development; IMP:FlyBase. GO:0009790; P:embryo development; IMP:FlyBase. GO:0036011; P:imaginal disc-derived leg segmentation; IMP:FlyBase. GO:0030177; P:positive regulation of Wnt receptor signaling pathway; IMP:FlyBase. GO:0045498; P:sex comb development; IMP:FlyBase. GO:0048190; P:wing disc dorsal/ventral pattern formation; IGI:FlyBase. |
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